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Product Details
H00000054-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
2D9
Immunogen
ACP5 (AAH25414.1, 72 a.a. approximately 158 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: NFYFTGVQDI NDKRFQETFE DVFSDRSLRK VPWYVLAGNH DHLGNVSAQI AYSKISKRWN FPSPFYRLHF KIPQTNVSVA IFMLDTV
Target Information
Tartrate-resistant acid phosphatase (TRAP) is a basic iron-binding protein with high activity towards phosphoproteins, ATP and 4-nitrophenyl phosphatase. It is detected in human alveolar macrophages, osteoclasts, spleen and liver. Its expression is increased in spleen and monocytes of patients with Gaucher's disease; spleenocytes and circulating leukocytes of patients with hairy cell leukemia; spleen of patients with Hodgkin's lymphoma and in the sera of patients undergoing active bone turnover.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: human purple acid phosphatase; Tartrate-resistant acid ATPase; tartrate-resistant acid phosphatase 5a; tartrate-resistant acid phosphatase 5b; Tartrate-resistant acid phosphatase type 5; TR-AP; TRAPase; TrATPase; Type 5 acid phosphatase
Gene Aliases: ACP5; HPAP; TRACP5a; TRACP5b; TRAP; TrATPase
UniProt ID: (Human) P13686
Entrez Gene ID: (Human) 54
ossification
riboflavin metabolic process
negative regulation of cell adhesion
response to zinc ion
dephosphorylation
osteoclast differentiation
positive regulation of cell migration
response to lipopolysaccharide
negative regulation of interleukin-1 beta production
negative regulation of interleukin-12 production
negative regulation of tumor necrosis factor production
negative regulation of superoxide anion generation
multicellular organismal response to stress
response to L-ascorbic acid
response to cytokine
negative regulation of nitric oxide biosynthetic process
bone resorption
negative regulation of inflammatory response
defense response to Gram-positive bacterium
bone morphogenesis
response to cholesterol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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