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Product Details
H00023305-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ACSL6 (AAH26161.1, 1 a.a. approximately 606 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MYQVFRRGLS ISGNGPCLGF RKPKQPYQWL SYQEVADRAE FLGSGLLQHN CKACTDQFIG VFAQNRPEWI IVELACYTYS MVVVPLYDTL GPGAIRYIIN TADISTVIVD KPQKAVLLLE HVERKETPGL KLIILMDPFE EALKERGQKC GVVIKSMQAV EDCGQENHLA PVPPQPDDLS IVCFTSGTTG NPKGAMLTHG NVVADFSGFL KVTEKVIFPR QDDVLISFLP LAHMFERVIQ SVVYCHGGRV GFFQGDIRLL SDDMKALCPT IFPVVPRLLN RMYDKIFSQA NTPLKRWLLE FAAKRKQAEV RSGIIRNDSI WDELFFNKIQ ASLGGCVRMI VTGAAPASPT VLGFLRAALG CQVYEGYGQT ECTAGCTFTT PGDWTSGHVG APLPCNHIKL VDVEELNYWA CKGEGEICVR GPNVFKGYLK DPDRTKEALD SDGWLHTGDI GKWLPAGTLK IIDRKKHIFK LAQGEYVAPE KIENIYIRSQ PVAQIYVHGD SLKAFLVGIV VPDPEVMPSW AQKRGIEGTY ADLCTNKDLK KAILEDMVRL GKESGLHSFE QVKAIHIHSD MFSVQNGLLT PTLKAKRPEL REYFKKQIEE LYSISM
Target Information
FACL6 is involved in activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. It plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. FACL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derieved from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. Expression is low at earlier stages of erythroid development but is very high in reticulocytes. This protein is involved in myelodysplastic syndrome (MDS) with basophilia, acute myelogenous leukemia (AML) with eosinophilia, and acute eosinophilic leukemia (AEL). It is characterized by a chromosomal translocation t(5;12)(q31;p13) that involves ETV6 and ACSL6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Arachidonate--CoA ligase; fatty-acid-Coenzyme A ligase, long-chain 6; L LACS5; LACS 6; long fatty acyl-CoA synthetase 2; Long-chain acyl-CoA synthetase 6; Long-chain-fatty-acid--CoA ligase 6
Gene Aliases: ACS2; ACSL6; FACL6; KIAA0837; LACS 6; LACS2; LACS5
UniProt ID: (Human) Q9UKU0
Entrez Gene ID: (Human) 23305
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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