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ACSS1 Polyclonal Antibody

ACSS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ACSS1 Antibody (17138-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 17138-1-AP ( ACSS1 Antibody) at dilution of 1:200 (under 40x lens).

ACSS1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17138-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ACSS1 Fusion Protein Ag10896 (340-689 aa encoded by BC039261)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ITGHSYVVY GPLCNGATSV LFESTPVYPN AGRYWETVER LKINQFYGAP TAVRLLLKYG DAWVKKYDRS SLRTLGSVGE PINCEAWEWL HRVVGDSRCT LVDTWWQTET GGICIAPRPS EEGAEILPAM AMRPFFGIVP VLMDEKGSVM EGSNVSGALC ISQAWPGMAR TIYGDHQRFV DAYFKAYPGY YFTGDGAYRT EGGYYQITGR MDDVINISGH RLGTAEIEDA IADHPAVPES AVIGYPHDIK GEAAFAFIVV KDSAGDSDVV VQELKSMVAT KIAKYAVPDE ILVVKRLPKT RSGKVMRRLL RKIITSEAQE LGDTTTLEDP SIIAEILSVY QKCKDKQAAA K (340-689 aa encoded by BC039261)

Target Information

This gene encodes a mitochondrial acetyl-CoA synthetase enzyme. A similar protein in mice plays an important role in the tricarboxylic acid cycle by catalyzing the conversion of acetate to acetyl CoA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Active post-transcriptional regulation and ACLY-mediated acetyl-CoA synthesis as a pivotal target of Shuang-Huang-Sheng-Bai formula for lung adenocarcinoma treatment.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Liu D,Dong C,Wang F,Liu W,Jin X,Qi SL,Liu L,Jin Q,Wang S,Wu J,Wang C,Yang J,Deng H,Cai Y,Yang L,Qin J,Zhang C,Yang X,Wang MS,Yu G,Xue YW,Wang Z,Ge GB,Xu Z,Chen WL

Mon May 01 00:00:00 UTC 2023

Acetyl-CoA synthetases ACSS1 and ACSS2 are 4-hydroxytamoxifen responsive factors that promote survival in tamoxifen treated and estrogen deprived cells.

Translational oncology

Calhoun S,Duan L,Maki CG

Sun May 01 00:00:00 UTC 2022

Inferring latent temporal progression and regulatory networks from cross-sectional transcriptomic data of cancer samples.

PLoS computational biology

Sun X,Zhang J,Nie Q

Mon Mar 01 00:00:00 UTC 2021

Inferring latent temporal progression and regulatory networks from cross-sectional transcriptomic data of cancer samples.

PLoS computational biology

Sun X,Zhang J,Nie Q

Mon Mar 01 00:00:00 UTC 2021

Acetyl-CoA synthases are essential for maintaining histone acetylation under metabolic stress during zygotic genome activation in pigs.

Journal of cellular physiology

Zhou W,Nie ZW,Zhou DJ,Cui XS

Fri Oct 01 00:00:00 UTC 2021

Acetyl-CoA synthases are essential for maintaining histone acetylation under metabolic stress during zygotic genome activation in pigs.

Journal of cellular physiology

Zhou W,Nie ZW,Zhou DJ,Cui XS

Fri Oct 01 00:00:00 UTC 2021

NRF2/ACSS2 axis mediates the metabolic effect of alcohol drinking on esophageal squamous cell carcinoma.

The Biochemical journal

Odera JO,Xiong Z,Huang C,Gu N,Yang W,Githang'a J,Odera E,Paiboonrungruang C,Chen X

Fri Aug 28 00:00:00 UTC 2020

Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.

Frontiers in pharmacology

Pang HQ,Yue SJ,Tang YP,Chen YY,Tan YJ,Cao YJ,Shi XQ,Zhou GS,Kang A,Huang SL,Shi YJ,Sun J,Tang ZS,Duan JA

Thu Oct 01 00:00:00 UTC 2020

Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.

Frontiers in pharmacology

Pang HQ,Yue SJ,Tang YP,Chen YY,Tan YJ,Cao YJ,Shi XQ,Zhou GS,Kang A,Huang SL,Shi YJ,Sun J,Tang ZS,Duan JA

Thu Oct 01 00:00:00 UTC 2020

Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.

The EMBO journal

Schweisgut J,Schutt C,Wüst S,Wietelmann A,Ghesquière B,Carmeliet P,Dröse S,Korach KS,Braun T,Boettger T

Tue May 02 00:00:00 UTC 2017

Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.

The EMBO journal

Schweisgut J,Schutt C,Wüst S,Wietelmann A,Ghesquière B,Carmeliet P,Dröse S,Korach KS,Braun T,Boettger T

Tue May 02 00:00:00 UTC 2017

Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.

The Journal of biological chemistry

Lakhter AJ,Hamilton J,Konger RL,Brustovetsky N,Broxmeyer HE,Naidu SR

Fri Oct 14 00:00:00 UTC 2016

Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth.

The Journal of biological chemistry

Lakhter AJ,Hamilton J,Konger RL,Brustovetsky N,Broxmeyer HE,Naidu SR

Fri Oct 14 00:00:00 UTC 2016

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia.

Nature communications

Gao X,Lin SH,Ren F,Li JT,Chen JJ,Yao CB,Yang HB,Jiang SX,Yan GQ,Wang D,Wang Y,Liu Y,Cai Z,Xu YY,Chen J,Yu W,Yang PY,Lei QY

Thu Jun 30 00:00:00 UTC 2016

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia.

Nature communications

Gao X,Lin SH,Ren F,Li JT,Chen JJ,Yao CB,Yang HB,Jiang SX,Yan GQ,Wang D,Wang Y,Liu Y,Cai Z,Xu YY,Chen J,Yu W,Yang PY,Lei QY

Thu Jun 30 00:00:00 UTC 2016

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia.

Nature communications

Gao X,Lin SH,Ren F,Li JT,Chen JJ,Yao CB,Yang HB,Jiang SX,Yan GQ,Wang D,Wang Y,Liu Y,Cai Z,Xu YY,Chen J,Yu W,Yang PY,Lei QY

Thu Jun 30 00:00:00 UTC 2016

Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia.

Nature communications

Gao X,Lin SH,Ren F,Li JT,Chen JJ,Yao CB,Yang HB,Jiang SX,Yan GQ,Wang D,Wang Y,Liu Y,Cai Z,Xu YY,Chen J,Yu W,Yang PY,Lei QY

Thu Jun 30 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: AceCS2; Acetate--CoA ligase 2; Acetyl-CoA synthetase 2; Acetyl-coenzyme A synthetase 2-like, mitochondrial; Acyl-CoA synthetase short-chain family member 1; Propionate--CoA ligase

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Gene Aliases: 1110032O15Rik; Acas2; ACAS2L; ACECS1; AceCS2; AceCS2L; ACSS1; AI788978; KIAA1846

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UniProt ID: (Human) Q9NUB1, (Mouse) Q99NB1

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Entrez Gene ID: (Human) 84532, (Mouse) 68738, (Rat) 296259

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Function(s)

acetate-CoA ligase activity protein binding ATP binding AMP binding nucleotide binding catalytic activity ligase activity

Process(es)

ethanol oxidation acetyl-CoA biosynthetic process acetate biosynthetic process acetyl-CoA biosynthetic process from acetate propionate biosynthetic process metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ACSS1 Polyclonal Antibody

ACSS1 Antibody (17138-1-AP) in IHC (P)

Product Details

17138-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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