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Abnova
ACTN4 Monoclonal Antibody (4D10)
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Product Details
H00000081-M01A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4D10
Immunogen
ACTN4 (NP_004915, 592 a.a. approximately 701 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Storage buffer
ascites
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: KEAQRIAESN HIKLSGSNPY TTVTPQIINS KWEKVQQLVP KRDHALLEEQ SKQQSNEHLR RQFASQANVV GPWIQTKMEE IGRISIEMNG TLEDQLSHLK QYERSIVDYK
Target Information
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actinin-Alpha-4; alpha actinin 4; Alpha-actinin-4; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; Non-muscle alpha-actinin 4
Gene Aliases: ACTININ-4; ACTN4; C77391; FSGS; FSGS1
UniProt ID: (Human) O43707, (Mouse) P57780, (Rat) Q9QXQ0
Entrez Gene ID: (Human) 81, (Mouse) 60595, (Rat) 63836
RNA polymerase II regulatory region sequence-specific DNA binding
nucleoside binding
actin binding
integrin binding
calcium ion binding
protein binding
ligand-dependent nuclear receptor transcription coactivator activity
chromatin DNA binding
nuclear hormone receptor binding
protein homodimerization activity
retinoic acid receptor binding
ion channel binding
poly(A) RNA binding
protein N-terminus binding
actin filament binding
protein complex binding
metal ion binding
transport
protein transport
peroxisome proliferator activated receptor signaling pathway
regulation of apoptotic process
retinoic acid receptor signaling pathway
positive regulation of pinocytosis
actin filament bundle assembly
negative regulation of cellular component movement
positive regulation of cellular component movement
bicellular tight junction assembly
protein localization to bicellular tight junction
regulation of nucleic acid-templated transcription
response to hypoxia
platelet degranulation
vesicle transport along actin filament
positive regulation of cell migration
positive regulation of sodium:proton antiporter activity
negative regulation of substrate adhesion-dependent cell spreading
positive regulation of NIK/NF-kappaB signaling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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