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Invitrogen
ACVR1B Recombinant Rabbit Monoclonal Antibody (3U6I8)
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Product Details
MA5-38039
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
3U6I8
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ACVR1B (P36896)
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897957
Product Specific Information
Positive Samples: 293T, HepG2, U-87MG, Mouse brain, Rat brain
Immunogen sequence: MAESAGASSF FPLVVLLLAG SGGSGPRGVQ ALLCACTSCL QANYTCETDG ACMVSIFNLD GMEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYTDY
Target Information
ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type IB; activin A receptor, type 1B; activin A receptor, type IB; activin A receptor, type II-like kinase 4; Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTR-IB; ACTRI; ACVR1A; ACVRLK2; ALK-4; ALK2; FOP; Serine/threonine-protein kinase receptor R2; SKR1; SKR2; TSRI
Gene Aliases: 6820432J04; ActR-IB; ACTRIB; ACVR1B; ACVRLK4; ALK4; SKR2
UniProt ID: (Human) P36896, (Rat) P80202, (Mouse) Q61271
Entrez Gene ID: (Human) 91, (Rat) 29381, (Mouse) 11479
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
activin receptor activity, type I
activin-activated receptor activity
growth factor binding
ubiquitin protein ligase binding
inhibin binding
SMAD binding
metal ion binding
activin binding
transforming growth factor beta-activated receptor activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
G1/S transition of mitotic cell cycle
in utero embryonic development
hair follicle development
regulation of transcription, DNA-templated
protein phosphorylation
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
central nervous system development
negative regulation of gene expression
positive regulation of pathway-restricted SMAD protein phosphorylation
peptidyl-threonine phosphorylation
signal transduction by protein phosphorylation
negative regulation of cell growth
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
nodal signaling pathway
positive regulation of erythrocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
development of primary female sexual characteristics
protein autophosphorylation
extrinsic apoptotic signaling pathway
positive regulation of trophoblast cell migration
regulation of signal transduction
positive regulation of gene expression
cell surface receptor signaling pathway
mesoderm development
embryo development
phosphorylation
intracellular signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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