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Invitrogen
ACVR1C Polyclonal Antibody
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Product Details
PA5-20597
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 15 amino acid peptide near the amino terminus of the human ACVR1C.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153980
Product Specific Information
A suggested positive control is human placenta lysate.
PA5-20597 can be used with blocking peptide PEP-0717.
Target Information
ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type IC; activin A receptor, type IC; Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR-IC; ACTRI; ACVR1A; ACVR1C; acvr1c {ECO:0000312|EMBL:AAC52803.1}; ACVRLK2; ALK-7; ALK2; FOP; SKR1; TGF-beta type 1 receptor; TSRI
Gene Aliases: ACVR1C; ACVRLK7; Alk-7; ALK7; C230097P10; habrec1
UniProt ID: (Human) Q8NER5, (Rat) P70539, (Mouse) Q8K348
Entrez Gene ID: (Human) 130399, (Rat) 245921, (Mouse) 269275
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
ATP binding
activin receptor activity, type I
growth factor binding
nodal binding
metal ion binding
transforming growth factor beta-activated receptor activity
SMAD binding
activin binding
BMP receptor binding
nucleotide binding
protein kinase activity
transmembrane receptor protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
response to dietary excess
protein phosphorylation
response to glucose
lipid storage
signal transduction by protein phosphorylation
cell differentiation
apoptotic nuclear changes
response to insulin
nodal signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of insulin secretion
negative regulation of trophoblast cell migration
negative regulation of chorionic trophoblast cell proliferation
ovarian follicle development
in utero embryonic development
apoptotic process
transforming growth factor beta receptor complex assembly
determination of left/right symmetry
response to organic cyclic compound
cerebellum development
hippocampus development
midbrain development
activin receptor signaling pathway
response to lipid
response to drug
regulation of apoptotic process
trophectodermal cell proliferation
transmembrane receptor protein serine/threonine kinase signaling pathway
phosphorylation
positive regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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