Invitrogen

ACVR1C Polyclonal Antibody

View all (11) ACVR1C antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-87475

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 22-113 of human ACVR1C (NP_6603022)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.76 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2804181

Product Specific Information

Immunogen sequence: LSPGLKCVCL LCDSSNFTCQ TEGACWASVM LTNGKEQVIK SCVSLPELNA QVFCHSSNNV TKTECCFTDF CNNITLHLPT ASPNAPKLGP ME; Positive Samples: SH-SY5Y; Cellular Location: Membrane, Single-pass type I membrane protein

Target Information

ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activin A receptor type IC; activin A receptor, type IC; Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR-IC; ACTRI; ACVR1A; ACVR1C; acvr1c {ECO:0000312|EMBL:AAC52803.1}; ACVRLK2; ALK-7; ALK2; FOP; SKR1; TGF-beta type 1 receptor; TSRI

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Gene Aliases: ACVR1C; ACVRLK7; Alk-7; ALK7; C230097P10; habrec1

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UniProt ID: (Human) Q8NER5, (Rat) P70539, (Mouse) Q8K348

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Entrez Gene ID: (Human) 130399, (Rat) 245921, (Mouse) 269275

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Function(s)
protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity ATP binding activin receptor activity, type I growth factor binding nodal binding metal ion binding transforming growth factor beta-activated receptor activity SMAD binding activin binding BMP receptor binding nucleotide binding protein kinase activity transmembrane receptor protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
response to dietary excess protein phosphorylation response to glucose lipid storage signal transduction by protein phosphorylation cell differentiation apoptotic nuclear changes response to insulin nodal signaling pathway positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of insulin secretion negative regulation of trophoblast cell migration negative regulation of chorionic trophoblast cell proliferation ovarian follicle development in utero embryonic development apoptotic process transforming growth factor beta receptor complex assembly determination of left/right symmetry response to organic cyclic compound cerebellum development hippocampus development midbrain development activin receptor signaling pathway response to lipid response to drug regulation of apoptotic process trophectodermal cell proliferation transmembrane receptor protein serine/threonine kinase signaling pathway phosphorylation positive regulation of apoptotic process
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