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OriGene
ACVR2A Monoclonal Antibody (OTI1F2), TrueMAB™
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FIGURE: 1 / 5
ACVR2A Antibody (CF807404) in IHC (P)
Immunohistochemical staining of paraffin-embedded human thyroid tissue within the normal limits using anti-ACVR2A mouse monoclonal antibody.This figure shows negative staining. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807404)(1:2000).
Product Details
CF807404
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI1F2
Immunogen
Human recombinant protein fragment corresponding to amino acids 214-513 of human ACVR2A produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor Serine/Threonine kinases. ACVR2A is involved in the activin and myostatin signaling pathway. (ACVR2A Aliases: ACVR2, ACTRII). These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type IIA; activin A receptor, type IIA; Activin receptor type IIA; Activin receptor type-2A; ACTR-IIA
Gene Aliases: ACTRII; ACVR2; ACVR2A
UniProt ID: (Human) P27037
Entrez Gene ID: (Human) 92
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
coreceptor activity
activin-activated receptor activity
growth factor binding
PDZ domain binding
inhibin binding
protein self-association
metal ion binding
activin binding
BMP receptor activity
gastrulation with mouth forming second
positive regulation of protein phosphorylation
transmembrane receptor protein serine/threonine kinase signaling pathway
spermatogenesis
determination of left/right symmetry
mesoderm development
anterior/posterior pattern specification
positive regulation of pathway-restricted SMAD protein phosphorylation
signal transduction by protein phosphorylation
positive regulation of bone mineralization
BMP signaling pathway
regulation of BMP signaling pathway
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
sperm ejaculation
penile erection
positive regulation of erythrocyte differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system development
regulation of nitric-oxide synthase activity
Sertoli cell proliferation
cellular response to BMP stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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