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Invitrogen
ACVR2B Monoclonal Antibody (A5H7)
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FIGURE: 1 / 1
ACVR2B Antibody (MA5-42557) in WB
Western blot analysis of ACVR2B on Hela cell lysates. Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. ACVR2B Monoclonal Antibody (Product # MA5-42557) at 1:500 was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Mouse IgG - HRP Secondary Antibody at 1:20,000 dilution was used for 1 hour at room temperature. Predicted band size: 58 kDa Observed band size: 50 kDa.
Product Details
MA5-42557
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
A5H7
Immunogen
Synthetic peptide within human ACVR2B aa 331-380/512
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein G
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2911698
Product Specific Information
Positive Control: Hela cell lysates.
Subcellular Location: Cell membrane.
Target Information
ACVR2B is a type II member of the TGF-beta family of receptor ser/thr kinases and is involved in the activin and myostatin signaling pathway. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type IIB; activin A receptor, type IIB; activin A receptor, type IIBa; activin receptor IIB; Activin receptor type IIB; Activin receptor type-2B; Activine receptor 2b (transmembrane serine kinase); ACTR-IIB; ActRIIB type II activin receptor B; MGC116908; serine/threonine receptor kinase
Gene Aliases: ActR-IIB; actr2b; ACTRIIB; ACVR2B; HTX4; wu:fj97d11
UniProt ID: (Human) Q13705, (Rat) P38445, (Mouse) P27040
Entrez Gene ID: (Human) 93, (Rat) 25366, (Mouse) 11481, (Zebrafish) 30457
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
activin receptor activity, type II
growth factor binding
inhibin binding
metal ion binding
activin binding
transmembrane receptor protein serine/threonine kinase activity
transforming growth factor beta-activated receptor activity
transforming growth factor beta binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transforming growth factor beta receptor activity, type II
type I transforming growth factor beta receptor binding
SMAD binding
skeletal system development
gastrulation with mouth forming second
kidney development
lymphangiogenesis
blood vessel remodeling
regulation of transcription, DNA-templated
protein phosphorylation
signal transduction
determination of left/right symmetry
pattern specification process
mesoderm development
heart development
response to glucose
post-embryonic development
anterior/posterior pattern specification
regulation of signal transduction
sexual reproduction
signal transduction by protein phosphorylation
insulin secretion
lung development
positive regulation of bone mineralization
BMP signaling pathway
pancreas development
activation of protein kinase activity
positive regulation of activin receptor signaling pathway
organ growth
odontogenesis of dentin-containing tooth
positive regulation of osteoblast differentiation
embryonic foregut morphogenesis
skeletal system morphogenesis
palate development
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
retina vasculature development in camera-type eye
neural crest cell migration
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
phosphorylation
hindbrain development
activin receptor signaling pathway
cartilage development
negative regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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