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Proteintech
ADAMTS12 Polyclonal Antibody
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Product Details
24934-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ADAMTS12 Fusion Protein Ag20712 (1-229 aa encoded by BC058841)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPCAQRSWL ANLSVVAQLL NFGALCYGRQ PQPGPVRFPD RRQEHFIKGL PEYHVVGPVR VDASGHFLSY GLHYPITSSR RKRDLDGSED WVYYRISHEE KDLFFNLTVN QGFLSNSYIM EKRYGNLSHV KMMASSAPLC HLSGTVLQQG TRVGTAALSA CHGLTGFFQL PHGDFFIEPV KKHPLVEGGY HPHIVYRRQK VPETKEPTCG LKGIVTHMSS WVEESVLFFW (1-229 aa encoded by BC058841)
Target Information
This protein is a disintegrin and metalloproteinase with thrombospondin motifs-12 (ADAMTS12), which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; a disintegrin-like and metalloprotease with thrombospondin type 1 motif, 12; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif, 12; ADAM-TS 12; ADAM-TS12; ADAMs; ADAMTS-12; metalloendopeptidases; metalloprotease disintegrin 12; UNQ1918
Gene Aliases: ADAMTS-12; ADAMTS12; AI605170; PRO4389; UNQ1918/PRO4389
UniProt ID: (Human) P58397, (Mouse) Q811B3
Entrez Gene ID: (Human) 81792, (Mouse) 239337
proteolysis
cell-matrix adhesion
cell migration
proteoglycan catabolic process
negative regulation of chondrocyte differentiation
regulation of inflammatory response
proteolysis involved in cellular protein catabolic process
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to BMP stimulus
regulation of endothelial tube morphogenesis
negative regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of cellular response to vascular endothelial growth factor stimulus
negative regulation of cellular response to hepatocyte growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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