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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • ADAMTS4 Antibodies

          Invitrogen

          ADAMTS4 Polyclonal Antibody

          Advanced Verification
          15 Published Figures
          11 References
          View all (25) ADAMTS4 antibodies

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          Datasheet
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          Datasheet
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          Cite ADAMTS4 Polyclonal Antibody

          • Antibody Testing Data (2)
          • Published Figures (15)
          • Advanced Verification (2)
          ADAMTS4 Antibody in Immunocytochemistry (ICC/IF)
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          ADAMTS4 Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 19

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          ADAMTS4 Antibody (PA1-1749A) in ICC/IF

          Immunofluorescence analysis of ADAMTS4 was performed using 70% confluent log phase SH-SY5Y cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with ADAMTS4 Rabbit Polyclonal Antibody (Product # PA1-1749A) at 2 µg/mL in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Pro... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          ADAMTS4 Antibody in Immunocytochemistry (ICC/IF)
          ADAMTS4 Antibody in Western Blot (WB)
          ADAMTS4 Antibody in Immunocytochemistry (ICC/IF)
          ADAMTS4 Antibody in Immunocytochemistry (ICC/IF)
          ADAMTS4 Antibody in Immunohistochemistry (IHC)
          ADAMTS4 Antibody in Immunohistochemistry (IHC)
          ADAMTS4 Antibody in Immunohistochemistry (IHC)
          ADAMTS4 Antibody in Immunohistochemistry (IHC)
          ADAMTS4 Antibody in Immunohistochemistry (IHC)
          ADAMTS4 Antibody in Immunohistochemistry (IHC)
          ADAMTS4 Antibody in Western Blot (WB)
          ADAMTS4 Antibody in Western Blot (WB)
          ADAMTS4 Antibody in Western Blot (WB)
          ADAMTS4 Antibody in Western Blot (WB)
          ADAMTS4 Antibody in Western Blot (WB)
          ADAMTS4 Antibody in Western Blot (WB)
          ADAMTS4 Antibody in Western Blot (WB)
          ADAMTS4 Antibody
          ADAMTS4 Antibody

          Product Details

          PA1-1749A

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1-3 µg/mL
          View 6 publications 6 publications

          Immunohistochemistry (IHC)

          -
          View 3 publications 3 publications

          Immunohistochemistry (Paraffin) (IHC (P))

          -
          View 1 publication 1 publication

          Immunocytochemistry (ICC/IF)

          2 µg/mL
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Bovine, Human, Mouse, Pig

          Published species

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Synthetic peptide corresponding to residues C V(394) M A H V D P E E P(403) of mouse ADAMTS4.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Affinity chromatography

          Storage buffer

          PBS with 1mg/mL BSA

          Contains

          0.05% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_1070004

          Product Specific Information

          PA1-1749A detects ADAMTS4 from porcine, bovine, mouse and human samples. PA1-1749A is specific for ADAMTS4 and shows no cross-reactivity with other ADAMTS family members.

          PA1-1749A has been successfully used in Western blot procedures. By Western blot, this antibody detects ADAMTS4 at ~68, ~53 and 30 kDa protein representing ADAMTS4 and its proteolytic fragments. Depending on the extent of C-terminal processing, several smaller bands may also be seen using this antibody.

          PA1-1749A immunogen is a synthetic peptide corresponding to residues C V(394) M A H V D P E E P(403) of mouse ADAMTS4. PA1-1749A immunizing peptide (Cat. # PEP-234) is available for use in neutralization and control procedures. This polyclonal antibody has been referred to as: JSCVMA. PA1-1749A has been used in combination with PA1-1750 for detection of all ADAMTS4 processed forms.

          Target Information

          This gene encodes a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 4; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADAM-TS 4; ADAM-TS4; ADAMs; ADAMTS-4; ADMP-1; Aggrecanase 1; Aggrecanase-1; metalloendopeptidases

          View more View less

          Gene Aliases: 3830423K05; ADAM-TS4; ADAMTS-2; ADAMTS-4; ADAMTS4; ADMP-1; BOS_2624; KIAA0688; mKIAA0688; UNQ769/PRO1563

          View more View less

          UniProt ID: (Bovine) Q9TT93, (Human) O75173, (Mouse) Q8BNJ2

          View more View less

          Entrez Gene ID: (Bovine) 286806, (Human) 9507, (Mouse) 240913

          View more View less

          Function(s)
          metalloendopeptidase activity metallopeptidase activity zinc ion binding protease binding protein binding peptidase activity hydrolase activity metal ion binding
          Process(es)
          proteolysis defense response to bacterium skeletal system development extracellular matrix disassembly
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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