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ADAMTSL2 Antibody (PA5-21414) in IHC (P)
ADAMTSL2 Polyclonal Antibody detects ADAMTSL2 protein at cytosol (secreted) on SkHep1xenograft by immunohistochemical analysis. Sample: Paraffin-embedded SkHep1xenograft. ADAMTSL2 Polyclonal Antibody (Product # PA5-21414) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
Product Details
PA5-21414
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human ADAMTSL2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11155005
Product Specific Information
Recommended positive controls: H1299.
Predicted reactivity: Mouse (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ADAMTSL2, or A Disintegrin And Metalloproteinase with Thrombospondin Motifs Like 2, is a gene that codes for a secreted glycoprotein involved in the regulation of extracellular matrix (ECM) and associated proteases. The gene, initially identified by the Kazusa DNA Research Institute, plays a crucial role in various biological processes including ECM remodeling. Mutations or alterations in ADAMTSL2 are implicated in multiple diseases, including genetic disorders like geleophysic dysplasia and cancer. Its expression levels and genetic variants have been correlated with cancer progression, immune cell infiltration in tumors, and other pathological conditions like non-alcoholic steatohepatitis (NASH). ADAMTSL2 is a potential biomarker for disease prognosis and therapeutic targeting due to its significant role in ECM dynamics and disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; ADAM; ADAMs; ADAMTS-like 2; ADAMTS-like protein 2; ADAMTSL-2; metalloendopeptidases; TCP-1; TSP1-repeat-containing protein 1; TSP1-repeats containing protein; TSP1-repeats-containing protein 1
Gene Aliases: A930008K15Rik; ADAMTSL2; GPHYSD1; KIAA0605; tcp-1; Tcp1
UniProt ID: (Human) Q86TH1, (Mouse) Q7TSK7
Entrez Gene ID: (Human) 9719, (Mouse) 77794
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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