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Product Details
PA5-62847
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ADAMTSL2. Recombinant protein control fragment (Product #RP-104491).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2637675
Product Specific Information
Immunogen sequence: VMSAYAMCVR YDGVEVDDSY CDALTRPEPV HEFCAGRECQ PRWETSSWSE CS
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 100%.
Target Information
ADAMTSL2, or A Disintegrin And Metalloproteinase with Thrombospondin Motifs Like 2, is a gene that codes for a secreted glycoprotein involved in the regulation of extracellular matrix (ECM) and associated proteases. The gene, initially identified by the Kazusa DNA Research Institute, plays a crucial role in various biological processes including ECM remodeling. Mutations or alterations in ADAMTSL2 are implicated in multiple diseases, including genetic disorders like geleophysic dysplasia and cancer. Its expression levels and genetic variants have been correlated with cancer progression, immune cell infiltration in tumors, and other pathological conditions like non-alcoholic steatohepatitis (NASH). ADAMTSL2 is a potential biomarker for disease prognosis and therapeutic targeting due to its significant role in ECM dynamics and disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: a disintegrin and metalloproteinase; ADAM; ADAMs; ADAMTS-like 2; ADAMTS-like protein 2; ADAMTSL-2; metalloendopeptidases
Gene Aliases: ADAMTSL2; GPHYSD1; KIAA0605
UniProt ID: (Human) Q86TH1
Entrez Gene ID: (Human) 9719
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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