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Proteintech
ADC Monoclonal Antibody (1A2B11), CoraLite® Plus 488
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FIGURE: 1 / 1
ADC Antibody (CL48867884100UL) in Flow
1X10^6 A431 cells were intracellularly stained with 0.2 µg CoraLite 488 Anti-Human ADC (Product # CL48867884100UL), Clone:1A2B11) (red), or 0.2 µg Mouse IgG1 Isotype Control (CL488-66360, Clone: T1F8D3F10) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL48867884100UL
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1A2B11
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles, store in dark
Shipping conditions
Wet ice
Target Information
Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADC; Antizyme inhibitor 2; ARGDC; Arginine decarboxylase; Arginine decarboxylase-like protein; AzI2; ODC antizyme inhibitor-2; ODC-like protein; ODC-p; ODC-paralogue; ornithine decarboxylase like; ornithine decarboxylase paralog; Ornithine decarboxylase-like protein; ornithine decarboxylase-paralog
Gene Aliases: 4933429I20Rik; ADC; AZI2; AZIB1; AZIN2; B930082O19; KIAA1945; ODC-p; ODC1L; ODCP; RGD1564776
UniProt ID: (Human) Q96A70, (Mouse) Q8BVM4
Entrez Gene ID: (Human) 113451, (Mouse) 242669, (Rat) 366473, (Pig) 100144439
spermatogenesis
putrescine transport
putrescine biosynthetic process from ornithine
negative regulation of protein catabolic process
positive regulation of catalytic activity
agmatine biosynthetic process
trans-Golgi network membrane organization
positive regulation of polyamine transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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