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Product Details
PAC5-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to unique amino acid sequence on rat Particulate Adenylyl Cyclase 5 protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AC5; adcy5; Adenylate cyclase type 5; Adenylate cyclase type V; Adenylyl cyclase 5; adenylyl cyclase type V; ATP pyrophosphate-lyase 5
Gene Aliases: AC5; ADCY5; AW121902; FDFM
UniProt ID: (Human) O95622, (Rat) Q04400, (Mouse) P84309
Entrez Gene ID: (Human) 111, (Rat) 64532, (Mouse) 224129
adenosine receptor signaling pathway
cAMP biosynthetic process
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-activating dopamine receptor signaling pathway
adenylate cyclase-inhibiting dopamine receptor signaling pathway
locomotory behavior
negative regulation of neuron projection development
intracellular signal transduction
neuromuscular process controlling balance
renal water homeostasis
activation of adenylate cyclase activity
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cAMP-mediated signaling
activation of protein kinase A activity
regulation of insulin secretion involved in cellular response to glucose stimulus
cellular response to glucagon stimulus
cellular response to forskolin
cyclic nucleotide biosynthetic process
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