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Product Details
BS-20177R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human ADRB1, amino acids 181-250.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind the endogenous catecholamines epinephrine and norepinephrine. Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family. Nine receptor subtypes have been identified thus far including three alpha-1 AR subtypes (1A/D, 1B, and 1C), three alpha-2 ARs (2A, 2B, and 2C), and three beta AR subtypes (1, 2, and 3). ARs participate in either the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence. BARs participate in diverse processes including development, behavior, cardiac function, smooth muscle tone, and metabolism. In gene-knockout experiments, the majority of mice that lack the B1AR gene die prenatally and those that do survive until adulthood display abnormal cardiac function. Other studies have shown that the direct regulation of cardiac B1AR density by thyroid hormones occurs at the transcriptional level and is modulated by the catecholamine sensitive-adenylyl cyclase system. Evidence for the effects of cAMP on B1AR regulation has come from a study of members of the cAMP response element (CRE) modulator (CREM) family of transcription factors in transformed cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adrenergic receptor, beta 1; adrenergic, beta-1-, receptor; beta 1-adrenergic receptor beta 1-AR; beta 1-AR; Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; cardiac beta adrenergic receptor
Gene Aliases: Adrb-1; ADRB1; ADRB1R; B1AR; beta-AR; BETA1AR; RATB1AR; RHR
UniProt ID: (Human) P08588, (Mouse) P34971, (Rat) P18090
Entrez Gene ID: (Human) 153, (Mouse) 11554, (Rat) 24925
beta-adrenergic receptor activity
beta1-adrenergic receptor activity
receptor signaling protein activity
Ras guanyl-nucleotide exchange factor activity
protein binding
PDZ domain binding
alpha-2A adrenergic receptor binding
protein heterodimerization activity
epinephrine binding
norepinephrine binding
signal transducer activity
G-protein coupled receptor activity
adrenergic receptor activity
drug binding
dopamine binding
temperature homeostasis
positive regulation of heart rate by epinephrine-norepinephrine
positive regulation of the force of heart contraction by epinephrine-norepinephrine
diet induced thermogenesis
vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
activation of adenylate cyclase activity
cell-cell signaling
response to cold
positive regulation of cAMP biosynthetic process
heat generation
negative regulation of multicellular organism growth
fear response
positive regulation of GTPase activity
positive regulation of cAMP-mediated signaling
brown fat cell differentiation
adenylate cyclase-activating adrenergic receptor signaling pathway
positive regulation of the force of heart contraction by norepinephrine
positive regulation of systemic arterial blood pressure
glycogen catabolic process
apoptotic process
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
Rho protein signal transduction
memory
positive regulation of heart rate
sensory perception of pain
protein localization to organelle
negative regulation of urine volume
wound healing
positive regulation of apoptotic process
positive regulation of adenylate cyclase activity
positive regulation of heart contraction
negative regulation of smooth muscle contraction
positive regulation of saliva secretion
regulation of calcium ion transport
lipid homeostasis
inhibitory postsynaptic potential
positive regulation of cell growth involved in cardiac muscle cell development
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
positive regulation of renin secretion into blood stream
positive regulation of long-term synaptic potentiation
positive regulation of cation channel activity
aging
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