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Invitrogen
ADSL Monoclonal Antibody (OTI2D10)
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ADSL Antibody (MA5-25263) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human lymphoma tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a ADSL monoclonal antibody (Product # MA5-25263).
Product Details
MA5-25263
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Cynomolgus monkey,
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2D10
Immunogen
Full length human recombinant protein of ADSL produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
0.55 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2722822
Target Information
ADSL (adenylosuccinate lyase), also known as AMPS, ASL or ASASE, is a 484 amino acid protein that is involved in both purine biosynthesis and in the formation of adenosine monophosphate (AMP) from inosine monophosphate. Expressed ubiquitously, ADSL catalyzes two key reactions in AMP biosynthesis, namely the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and the subsequent removal of fumarate from adenylosuccinate to yield AMP. Defects in the gene encoding ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency), an autosomal recessive disorder characterized by epilepsy, growth retardation and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adenylosuccinase; Adenylosuccinate lyase; ADSL; ASase; test; uncharacterized protein LOC101864843
Gene Aliases: ADSL; AMPS; ASASE; ASL; null
UniProt ID: (Human) P30566
Entrez Gene ID: (Human) 158, (Dog) 474499, (Rat) 315150, (Cynomolgus monkey) 101864843
response to hypoxia
purine nucleotide metabolic process
AMP biosynthetic process
'de novo' IMP biosynthetic process
response to nutrient
metabolic process
aerobic respiration
ribonucleoside monophosphate biosynthetic process
response to muscle activity
response to starvation
'de novo' AMP biosynthetic process
protein tetramerization
purine nucleotide biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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