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Proteintech
AGAP2 Polyclonal Antibody
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Product Details
14690-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AGAP2 Fusion Protein Ag6142 (848-1192 aa encoded by BC028020)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MVKKQRRKK LTTPSKTEGS AGQAEEENFE FLIVSSTGQT WHFEAASFEE RDAWVQAIES QILASLQCCE SSKVKLRTDS QSEAVAIQAI RNAKGNSICV DCGAPNPTWA SLNLGALICI ECSGIHRNLG THLSRVRSLD LDDWPRELTL VLTAIGNDTA NRVWESDTRG RAKPSRDSSR EERESWIRAK YEQLLFLAPL STSEEPLGRQ LWAAVQAQDV ATVLLLLAHA RHGPLDTSVE DPQLRSPLHL AAELAHVVIT QLLLWYGADV AARDAQGRTA LFYARQAGSQ LCADILLQHG CPGEGGSAAT TPSAATTPSI TATPSPRRRS SAASVGRADA PVALV (848-1192 aa encoded by BC028020)
Target Information
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AGAP-2; Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; centaurin gamma1; centaurin, gamma 1; Centaurin-gamma-1; Cnt-g1; FLJ16430; GGAP2; GTP-binding and GTPase activating protein 2; GTP-binding and GTPase-activating protein 2; nuclear GTPase PIKE; Phosphatidylinositol 3-kinase enhancer; phosphatidylinositol-3-kinase enhancer; phosphoinositide 3-kinase enhancer; PIKE
Gene Aliases: AGAP-2; AGAP2; CENTG1; cnt-g1; GGAP2; KIAA0167; mKIAA0167; PIKE
UniProt ID: (Human) Q99490, (Mouse) Q3UHD9, (Rat) Q8CGU4
Entrez Gene ID: (Human) 116986, (Mouse) 216439, (Rat) 65218
small GTPase mediated signal transduction
positive regulation of phosphatidylinositol 3-kinase signaling
endosomal transport
actin cytoskeleton organization
positive regulation of mammary gland epithelial cell proliferation
negative regulation of protein catabolic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
regulation of phosphatidylinositol 3-kinase activity
positive regulation of protein kinase activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
mammary gland alveolus development
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
protein transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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