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Recommended positive controls: A549, HepG2.
Predicted reactivity: Mouse (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATP/GTP binding protein-like 4; ATP/GTP-binding protein-like 4; Cytosolic carboxypeptidase 6; Protein deglutamylase CCP6
Gene Aliases: AGBL4; CCP6
UniProt ID: (Human) Q5VU57
Entrez Gene ID: (Human) 84871
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