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Invitrogen
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Immunogen sequence: GNLGRVDQVS EFEYDLFIRP DTCNPRFRVW FNFTVENVKE SQRVIFNIVN FSKTKSLYRD GMAPMVKSTS RPKWQRLPPK
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 38%.
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATP/GTP binding protein-like 4; ATP/GTP-binding protein-like 4; Cytosolic carboxypeptidase 6; Protein deglutamylase CCP6
Gene Aliases: AGBL4; CCP6
UniProt ID: (Human) Q5VU57
Entrez Gene ID: (Human) 84871
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