Invitrogen

AGO1/AGO2 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-40075

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

ELISA (ELISA)

1:3,500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH-conjugated synthetic peptide containing a sequence from the C-terminal part of both EIF2C1 and EIF2C2 corresponding to human IEF2C1/2 (eukaryotic translation initiation factor 2C1 and 2).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2576597

Target Information

IEF2C1 and 2 are members of the Argonaute family. These proteins are involved in short-interfering-RNA-mediated gene silencing. This process is mediated by the RISC (RNA induced silencing complex), a multicomponent nuclease that is able to degrade double stranded RNAs. The mRNA degradation is triggered by the association of specific siRNAs with their homologous mRNAs. IEF2C2 has been shown to be essential for embryonic development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: argonaute 1; argonaute 2; Argonaute RISC catalytic component 1; Argonaute RISC catalytic component 2; Argonaute1; Argonaute2; CTA-204B4.6; eIF-2C 1; eIF-2C 2; eIF2C 1; eIF2C 2; Eukaryotic translation initiation factor 2C 1; Eukaryotic translation initiation factor 2C 2; eukaryotic translation initiation factor 2C, 1; eukaryotic translation initiation factor 2C, 2; Golgi Endoplasmic Reticulum protein 95 kDa; hAgo2; PAZ Piwi domain protein; PPD; Protein argonaute-1; Protein argonaute-2; Protein slicer; Putative RNA-binding protein Q99

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Gene Aliases: AGO1; AGO2; EIF2C; EIF2C1; EIF2C2; GERP95; hAgo1; Q10; Q99

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UniProt ID: (Human) Q9UL18, (Human) Q9UKV8

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Entrez Gene ID: (Human) 26523, (Human) 27161

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core binding core promoter binding RNA binding double-stranded RNA binding single-stranded RNA binding endoribonuclease activity protein binding miRNA binding poly(A) RNA binding RNA 7-methylguanosine cap binding mRNA binding translation initiation factor activity protein C-terminus binding siRNA binding metal ion binding endoribonuclease activity, cleaving siRNA-paired mRNA endoribonuclease activity, cleaving miRNA-paired mRNA
Process(es)
nuclear-transcribed mRNA catabolic process transcription, DNA-templated Wnt signaling pathway, calcium modulating pathway RNA secondary structure unwinding miRNA metabolic process gene silencing by RNA pre-miRNA processing posttranscriptional gene silencing by RNA production of miRNAs involved in gene silencing by miRNA miRNA mediated inhibition of translation mRNA cleavage involved in gene silencing by miRNA miRNA loading onto RISC involved in gene silencing by miRNA positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol-mediated signaling mRNA cleavage involved in gene silencing by siRNA translation translational initiation post-embryonic development siRNA loading onto RISC involved in RNA interference negative regulation of translational initiation positive regulation of nuclear-transcribed mRNA poly(A) tail shortening RNA phosphodiester bond hydrolysis, endonucleolytic positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
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