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Invitrogen
AGR2/AGR3 Monoclonal Antibody (AGR3.4)
Product Details
MA1-10047
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
AGR3.4
Immunogen
Purified human AGR3 protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.2% BSA
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11153589
Product Specific Information
This antibody recognizes the PLMII epitope of AGR3 (AG3) and AGR2 (AG2) proteins (19-20 kDa); secreted cytoplasmic proteins which can serve as markers of carcinogenesis.
Target Information
AGR2 (Anterior Gradient 2), also known as AG2 (hAG-2, HAG2 in human), or GOB-4, and AGR3 (Anterior Gradient 3), also known as AG3 (hAG-3, HAG3 in human), or BCMP11, are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours; AGR2 was reported also as a marker of other carcinomas. Xenopus homolog of these proteins is associated with anteroposterior fate determination during early development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AG-2; AG-3; Anterior gradient 3 homolog; anterior gradient homolog 2; anterior gradient homolog 3; Anterior gradient protein 2 homolog; Anterior gradient protein 3; anterior gradient protein 3 homolog; Breast cancer membrane protein 11; epididymis secretory protein Li 116; HPC8; protein disulfide isomerase family A, member 17; Protein disulfide isomerase family A, member 18; secreted cement gland homolog; Secreted cement gland protein XAG-2 homolog
Gene Aliases: AG-3; AG2; AG3; AGR2; AGR3; BCMP11; GOB-4; HAG-2; hAG-3; HAG3; HEL-S-116; PDIA17; PDIA18; UNQ515/PRO1030; UNQ642/PRO1272; XAG-2
UniProt ID: (Human) O95994, (Human) Q8TD06
Entrez Gene ID: (Human) 10551, (Human) 155465
biological_process
positive regulation of gene expression
positive regulation of cell-substrate adhesion
response to endoplasmic reticulum stress
positive regulation of epidermal growth factor receptor signaling pathway
digestive tract morphogenesis
positive regulation of developmental growth
lung goblet cell differentiation
negative regulation of cell death
mucus secretion
positive regulation of establishment of protein localization to plasma membrane
positive regulation of IRE1-mediated unfolded protein response
positive regulation of PERK-mediated unfolded protein response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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