Proteintech

AGR2 Polyclonal Antibody

AGR2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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AGR2 Antibody (12275-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 12275-1-AP ( AGR2 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

AGR2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12275-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

AGR2 Fusion Protein Ag2919 (37-195 aa encoded by BC015503)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YTLARDTTV KPGAKKDTKD SRPKLPQTLS RGWGDQLIWT QTYEEALYKS KTSNKPLMII HHLDECPHSQ ALKKVFAENK EIQKLAEQFV LLNLVYETTD KHLSPDGQYV PRIMFVDPSL TVRADITGRY SNRLYAYEPA DTALLLDNMK KALKLLKTEL (37-195 aa encoded by BC015503)

Target Information

AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. They are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular markers and potential therapeutic targets for hormone-responsive breast tumours. AGR2 is ubiquitously expressed with upregulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells.

Signal transduction and targeted therapy

Wang Z,Li Y,Zhao W,Jiang S,Huang Y,Hou J,Zhang X,Zhai Z,Yang C,Wang J,Zhu J,Pan J,Jiang W,Li Z,Ye M,Tan M,Jiang H,Dang Y

Mon May 01 00:00:00 UTC 2023

Patient-derived and mouse endo-ectocervical organoid generation, genetic manipulation and applications to model infection.

Nature protocols

Gurumurthy RK,Koster S,Kumar N,Meyer TF,Chumduri C

Fri Jul 01 00:00:00 UTC 2022

EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.

Food & function

Fang J,Zhang Z,Cheng Y,Yang H,Zhang H,Xue Z,Lu S,Dong Y,Song C,Zhang X,Zhou Y

Wed Apr 20 00:00:00 UTC 2022

Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia.

Nature cell biology

Chumduri C,Gurumurthy RK,Berger H,Dietrich O,Kumar N,Koster S,Brinkmann V,Hoffmann K,Drabkina M,Arampatzi P,Son D,Klemm U,Mollenkopf HJ,Herbst H,Mangler M,Vogel J,Saliba AE,Meyer TF

Mon Feb 01 00:00:00 UTC 2021

Early administration of dapagliflozin preserves pancreatic β-cell mass through a legacy effect in a mouse model of type 2 diabetes.

Journal of diabetes investigation

Kanno A,Asahara SI,Kawamura M,Furubayashi A,Tsuchiya S,Suzuki E,Takai T,Koyanagi-Kimura M,Matsuda T,Okada Y,Ogawa W,Kido Y

Wed May 01 00:00:00 UTC 2019

Early administration of dapagliflozin preserves pancreatic β-cell mass through a legacy effect in a mouse model of type 2 diabetes.

Journal of diabetes investigation

Kanno A,Asahara SI,Kawamura M,Furubayashi A,Tsuchiya S,Suzuki E,Takai T,Koyanagi-Kimura M,Matsuda T,Okada Y,Ogawa W,Kido Y

Wed May 01 00:00:00 UTC 2019

Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study.

Cancer letters

Negi H,Merugu SB,Mangukiya HB,Li Z,Zhou B,Sehar Q,Kamle S,Yunus FU,Mashausi DS,Wu Z,Li D

Wed May 01 00:00:00 UTC 2019

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.

EMBO molecular medicine

Maurel M,Obacz J,Avril T,Ding YP,Papadodima O,Treton X,Daniel F,Pilalis E,Hörberg J,Hou W,Beauchamp MC,Tourneur-Marsille J,Cazals-Hatem D,Sommerova L,Samali A,Tavernier J,Hrstka R,Dupont A,Fessart D,Delom F,Fernandez-Zapico ME,Jansen G,Eriksson LA,Thomas DY,Jerome-Majewska L,Hupp T,Chatziioannou A,Chevet E,Ogier-Denis E

Sat Jun 01 00:00:00 UTC 2019

Identification and prognostic value of anterior gradient protein 2 expression in breast cancer based on tissue microarray.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Guo J,Gong G,Zhang B

Sat Jul 01 00:00:00 UTC 2017

Identification and prognostic value of anterior gradient protein 2 expression in breast cancer based on tissue microarray.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Guo J,Gong G,Zhang B

Sat Jul 01 00:00:00 UTC 2017

Unique recurrence patterns of cervical intraepithelial neoplasia after excision of the squamocolumnar junction.

International journal of cancer

Herfs M,Somja J,Howitt BE,Suarez-Carmona M,Kustermans G,Hubert P,Doyen J,Goffin F,Kridelka F,Crum CP,Delvenne P

Sun Mar 01 00:00:00 UTC 2015

Unique recurrence patterns of cervical intraepithelial neoplasia after excision of the squamocolumnar junction.

International journal of cancer

Herfs M,Somja J,Howitt BE,Suarez-Carmona M,Kustermans G,Hubert P,Doyen J,Goffin F,Kridelka F,Crum CP,Delvenne P

Sun Mar 01 00:00:00 UTC 2015

A novel blueprint for 'top down' differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia.

The Journal of pathology

Herfs M,Vargas SO,Yamamoto Y,Howitt BE,Nucci MR,Hornick JL,McKeon FD,Xian W,Crum CP

Fri Feb 01 00:00:00 UTC 2013

A novel blueprint for 'top down' differentiation defines the cervical squamocolumnar junction during development, reproductive life, and neoplasia.

The Journal of pathology

Herfs M,Vargas SO,Yamamoto Y,Howitt BE,Nucci MR,Hornick JL,McKeon FD,Xian W,Crum CP

Fri Feb 01 00:00:00 UTC 2013

Cervical squamocolumnar junction-specific markers define distinct, clinically relevant subsets of low-grade squamous intraepithelial lesions.

The American journal of surgical pathology

Herfs M,Parra-Herran C,Howitt BE,Laury AR,Nucci MR,Feldman S,Jimenez CA,McKeon FD,Xian W,Crum CP

Sun Sep 01 00:00:00 UTC 2013

Cervical squamocolumnar junction-specific markers define distinct, clinically relevant subsets of low-grade squamous intraepithelial lesions.

The American journal of surgical pathology

Herfs M,Parra-Herran C,Howitt BE,Laury AR,Nucci MR,Feldman S,Jimenez CA,McKeon FD,Xian W,Crum CP

Sun Sep 01 00:00:00 UTC 2013

A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.

Proceedings of the National Academy of Sciences of the United States of America

Herfs M,Yamamoto Y,Laury A,Wang X,Nucci MR,McLaughlin-Drubin ME,Münger K,Feldman S,McKeon FD,Xian W,Crum CP

Tue Jun 26 00:00:00 UTC 2012

A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.

Proceedings of the National Academy of Sciences of the United States of America

Herfs M,Yamamoto Y,Laury A,Wang X,Nucci MR,McLaughlin-Drubin ME,Münger K,Feldman S,McKeon FD,Xian W,Crum CP

Tue Jun 26 00:00:00 UTC 2012

A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.

Proceedings of the National Academy of Sciences of the United States of America

Herfs M,Yamamoto Y,Laury A,Wang X,Nucci MR,McLaughlin-Drubin ME,Münger K,Feldman S,McKeon FD,Xian W,Crum CP

Tue Jun 26 00:00:00 UTC 2012

A discrete population of squamocolumnar junction cells implicated in the pathogenesis of cervical cancer.

Proceedings of the National Academy of Sciences of the United States of America

Herfs M,Yamamoto Y,Laury A,Wang X,Nucci MR,McLaughlin-Drubin ME,Münger K,Feldman S,McKeon FD,Xian W,Crum CP

Tue Jun 26 00:00:00 UTC 2012

Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach.

Journal of proteome research

Xue H,Lü B,Zhang J,Wu M,Huang Q,Wu Q,Sheng H,Wu D,Hu J,Lai M

Fri Jan 01 00:00:00 UTC 2010

Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approach.

Journal of proteome research

Xue H,Lü B,Zhang J,Wu M,Huang Q,Wu Q,Sheng H,Wu D,Hu J,Lai M

Fri Jan 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: AG-2; anterior gradient 2 homolog; anterior gradient homolog 2; Anterior gradient protein 2 homolog; epididymis secretory protein Li 116; HPC8; protein disulfide isomerase family A, member 17; Protein Gob-4; secreted cement gland homolog; Secreted cement gland protein XAG-2 homolog

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Gene Aliases: AG2; AGR2; Agr2h; GOB-4; Gob4; HAG-2; HEL-S-116; mAG-2; PDIA17; UNQ515/PRO1030; XAG-2

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UniProt ID: (Human) O95994, (Mouse) O88312

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Entrez Gene ID: (Human) 10551, (Mouse) 23795, (Rat) 298961

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Function(s)

dystroglycan binding epidermal growth factor receptor binding protein binding protein homodimerization activity molecular_function

Process(es)

positive regulation of gene expression positive regulation of cell-substrate adhesion positive regulation of epidermal growth factor receptor signaling pathway lung goblet cell differentiation negative regulation of cell death mucus secretion positive regulation of establishment of protein localization to plasma membrane positive regulation of IRE1-mediated unfolded protein response positive regulation of PERK-mediated unfolded protein response response to endoplasmic reticulum stress digestive tract morphogenesis positive regulation of developmental growth biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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AGR2 Polyclonal Antibody

AGR2 Antibody (12275-1-AP) in IHC (P)

Product Details

12275-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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