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G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Activator of G-protein signaling 3; DKFZP727I051; G-protein signalling modulator 1 (AGS3-like, C. elegans); G-protein-signaling modulator 1
Gene Aliases: AGS3; GPSM1
UniProt ID: (Human) Q86YR5
Entrez Gene ID: (Human) 26086
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