Invitrogen

AGTR2 Recombinant Rabbit Monoclonal Antibody (6C7)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-38402

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6C7

Immunogen

A synthesized peptide derived from human AGTR2
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 150mM NaCl

Contains

0.02% sodium azide

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898316

Product Specific Information

This antibody has been tested in direct-ELISA

Target Information

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion that acts through at least two types of receptors, AGTR1 and AGTR2. It is an important effector controlling blood pressure and volume in the cardiovascular system and plays a major role in the development of the mammalian kidney and urinary tract. Like AGTR1, AGTR2 is a seven transmembrane G protein-coupled receptor (GPCR), but AGTR2 does not demonstrate most of the classic features of GPCR signaling. AGTR2 is involved in a wide range of activities, including the induction of neurite outgrowth and the inhibition of cellular proliferation, in addition to the known function of mediation of vasoconstriction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Angiotensin ii at2; angiotensin II receptor, type 2; Angiotensin II type-2 receptor; AT2 receptor; Type-2 angiotensin II receptor

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Gene Aliases: AGTR2; AI316812; AT2; ATGR2; AW107640; MRX88

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UniProt ID: (Human) P50052, (Mouse) P35374

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Entrez Gene ID: (Human) 186, (Mouse) 11609

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Function(s)
angiotensin type II receptor activity protein binding transcription factor binding peptide hormone binding receptor antagonist activity signal transducer activity G-protein coupled receptor activity
Process(es)
blood vessel remodeling regulation of systemic arterial blood pressure by circulatory renin-angiotensin renin-angiotensin regulation of aldosterone production vasodilation by angiotensin involved in regulation of systemic arterial blood pressure brain renin-angiotensin system cellular sodium ion homeostasis inflammatory response cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger nitric oxide mediated signal transduction brain development regulation of blood pressure positive regulation of cell proliferation negative regulation of heart rate negative regulation of norepinephrine secretion cerebellar cortex development negative regulation of cell growth negative regulation of icosanoid secretion positive regulation of phosphoprotein phosphatase activity intracellular signal transduction regulation of metanephros size exploration behavior positive regulation of renal sodium excretion aldosterone secretion angiotensin-activated signaling pathway dopamine biosynthetic process regulation of transcription factor import into nucleus negative regulation of blood vessel endothelial cell migration positive regulation of nitric oxide biosynthetic process positive regulation of transcription, DNA-templated positive regulation of vasodilation negative regulation of fibroblast proliferation positive regulation of cytokine secretion positive regulation of nitric-oxide synthase activity negative regulation of neurotrophin TRK receptor signaling pathway cell growth involved in cardiac muscle cell development cellular response to dexamethasone stimulus positive regulation of metanephric glomerulus development positive regulation of branching involved in ureteric bud morphogenesis extracellular negative regulation of signal transduction positive regulation of extrinsic apoptotic signaling pathway signal transduction regulation of vasodilation regulation of apoptotic process negative regulation of neuron apoptotic process kidney morphogenesis
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