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Invitrogen
AGXT Polyclonal Antibody
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AGXT Antibody (PA5-97036) in IHC (P)
Immunohistochemistry analysis of AGXT in paraffin-embedded human liver. Samples were incubated with AGXT Polyclonal antibody (Product # PA5-97036) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-97036
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 183-392 of human AGXT (NP_0000211)
Conjugate
Form
Liquid
Concentration
0.82 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2808838
Product Specific Information
Immunogen sequence: DSVASLGGTP LYMDRQGIDI LYSGSQKALN APPGTSLISF SDKAKKKMYS RKTKPFSFYL DIKWLANFWG CDDQPRMYHH TIPVISLYSL RESLALIAEQ GLENSWRQHR EAAAYLHGRL QALGLQLFVK DPALRLPTVT TVAVPAGYDW RDIVSYVIDH FDIEIMGGLG PSTGKVLRIG LLGCNATREN VDRVTEALRA ALQHCPKKKL; Positive Samples: LO2, 293T; Cellular Location: Mitochondrion, Peroxisome
Target Information
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AGT; Alanine--glyoxylate aminotransferase; hepatic peroxisomal alanine:glyoxylate aminotransferase; L-alanine: glyoxylate aminotransferase 1; Serine--pyruvate aminotransferase; serine-pyruvate aminotransferase; serine:pyruvate aminotransferase; SPT
Gene Aliases: AGT; AGT1; AGXT; AGXT1; PH1; SPAT; SPT; TLH6
UniProt ID: (Human) P21549
Entrez Gene ID: (Human) 189
Notch signaling pathway
glyoxylate catabolic process
proteasomal protein catabolic process
glycine biosynthetic process, by transamination of glyoxylate
L-cysteine catabolic process
L-alanine catabolic process
pyruvate biosynthetic process
glyoxylate metabolic process
oxalic acid secretion
response to glucocorticoid
response to cAMP
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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