Proteintech

AHCYL1 Polyclonal Antibody

AHCYL1 Antibody in Immunocytochemistry (ICC/IF)

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AHCYL1 Antibody (10658-3-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using AHCYL1 antibody 10658-3-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

AHCYL1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

AHCYL1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10658-3-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 19 publications 19 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

1:10-1:100

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Chicken, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

AHCYL1 Fusion Protein Ag1017 (212-530 aa encoded by BC007576)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: IDRCVNMDG WQANMILDDG GDLTHWVYKK YPNVFKKIRG IVEESVTGVH RLYQLSKAGK LCVPAMNVND SVTKQKFDNL YCCRESILDG LKRTTDVMFG GKQVVVCGYG EVGKGCCAAL KALGAIVYIT EIDPICALQA CMDGFRVVKL NEVIRQVDVV ITCTGNKNVV TREHLDRMKN SCIVCNMGHS NTEIDVTSLR TPELTWERVR SQVDHVIWPD GKRVVLLAEG RLLNLSCSTV PTFVLSITAT TQALALIELY NAPEGRYKQD VYLLPKKMDE YVASLHLPSF DAHLTELTDD QAKYLGLNKN GPFKPNYYRY (212-530 aa encoded by BC007576)

Target Information

The protein encoded by this gene interacts with inositol 1,4,5-trisphosphate receptor, type 1 and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding two different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Quantitative reactive cysteinome profiling reveals a functional link between ferroptosis and proteasome-mediated degradation.

Cell death and differentiation

Wang Y,Wang C

Sun Jan 01 00:00:00 UTC 2023

Quantitative reactive cysteinome profiling reveals a functional link between ferroptosis and proteasome-mediated degradation.

Cell death and differentiation

Wang Y,Wang C

Sun Jan 01 00:00:00 UTC 2023

In ovo injection of betaine promotes adrenal steroidogenesis in pre-hatched chicken fetuses.

Poultry science

Abobaker H,Omer NA,Hu Y,Idriss AA,Zhao R

Wed Jun 01 00:00:00 UTC 2022

Protective Role of IRBIT on Sodium Bicarbonate Cotransporter-n1 for Migratory Cancer Cells.

Pharmaceutics

Hwang S,Shin DM,Hong JH

Thu Aug 27 00:00:00 UTC 2020

Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.

Poultry science

Hu Y,Feng Y,Ding Z,Lv L,Sui Y,Sun Q,Abobaker H,Cai D,Zhao R

Mon Jun 01 00:00:00 UTC 2020

A New Therapeutic Strategy Targeting Protein Deacetylation for Spinal Cord Injury.

Neuroscience

Liu X,Ma B,Zhang H,Chai R,Xiang L

Tue Dec 15 00:00:00 UTC 2020

A New Therapeutic Strategy Targeting Protein Deacetylation for Spinal Cord Injury.

Neuroscience

Liu X,Ma B,Zhang H,Chai R,Xiang L

Tue Dec 15 00:00:00 UTC 2020

Transgenerational Inheritance of Betaine-Induced Epigenetic Alterations in Estrogen-Responsive IGF-2/IGFBP2 Genes in Rat Hippocampus.

Molecular nutrition & food research

Yang Y,Jiang W,Yang S,Qi F,Zhao R

Wed Apr 01 00:00:00 UTC 2020

Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.

Journal of the science of food and agriculture

Yang S,Zhao N,Sun B,Yang Y,Hu Y,Zhao R

Sun Mar 15 00:00:00 UTC 2020

DNA Hypomethylation of GR Promoters is Associated with GR Activation and BDNF/AKT/ERK1/2-Induced Hippocampal Neurogenesis in Mice Derived From Folic-Acid-Supplemented Dams.

Molecular nutrition & food research

Yang Y,Yang S,Liu J,Feng Y,Qi F,Zhao R

Sat Jun 01 00:00:00 UTC 2019

Low IRBIT Levels Are Associated With Chemo-resistance in Gastric Cancer Patients.

Anticancer research

Nakazawa N,Ogata K,Yokobori T,Ide M,Baatar S,Ubukata Y,Kimura A,Kogure N,Sohda M,Kuwano H,Saeki H,Shirabe K

Thu Aug 01 00:00:00 UTC 2019

Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.

Journal of agricultural and food chemistry

Yang S,Zhao N,Yang Y,Hu Y,Dong H,Zhao R

Wed Mar 21 00:00:00 UTC 2018

Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.

Journal of agricultural and food chemistry

Yang S,Zhao N,Yang Y,Hu Y,Dong H,Zhao R

Wed Mar 21 00:00:00 UTC 2018

Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.

The Journal of nutrition

Hu Y,Sun Q,Hu Y,Hou Z,Zong Y,Omer NA,Abobaker H,Zhao R

Thu Mar 01 00:00:00 UTC 2018

Corticosterone-Induced Lipogenesis Activation and Lipophagy Inhibition in Chicken Liver Are Alleviated by Maternal Betaine Supplementation.

The Journal of nutrition

Hu Y,Sun Q,Hu Y,Hou Z,Zong Y,Omer NA,Abobaker H,Zhao R

Thu Mar 01 00:00:00 UTC 2018

Maternal betaine administration modulates hepatic type 1 iodothyronine deiodinase (Dio1) expression in chicken offspring through epigenetic modifications.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology

Hou Z,Sun Q,Hu Y,Yang S,Zong Y,Zhao R

Sun Apr 01 00:00:00 UTC 2018

Maternal betaine administration modulates hepatic type 1 iodothyronine deiodinase (Dio1) expression in chicken offspring through epigenetic modifications.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology

Hou Z,Sun Q,Hu Y,Yang S,Zong Y,Zhao R

Sun Apr 01 00:00:00 UTC 2018

Maternal betaine supplementation in rats induces intergenerational changes in hepatic IGF-1 expression and DNA methylation.

Molecular nutrition & food research

Zhao N,Yang S,Hu Y,Dong H,Zhao R

Tue Aug 01 00:00:00 UTC 2017

Maternal betaine supplementation in rats induces intergenerational changes in hepatic IGF-1 expression and DNA methylation.

Molecular nutrition & food research

Zhao N,Yang S,Hu Y,Dong H,Zhao R

Tue Aug 01 00:00:00 UTC 2017

Downregulation of miR-150 Expression by DNA Hypermethylation Is Associated with High 2-Hydroxy-(4-methylthio)butanoic Acid-Induced Hepatic Cholesterol Accumulation in Nursery Piglets.

Journal of agricultural and food chemistry

Jia Y,Ling M,Zhang L,Jiang S,Sha Y,Zhao R

Wed Oct 12 00:00:00 UTC 2016

Downregulation of miR-150 Expression by DNA Hypermethylation Is Associated with High 2-Hydroxy-(4-methylthio)butanoic Acid-Induced Hepatic Cholesterol Accumulation in Nursery Piglets.

Journal of agricultural and food chemistry

Jia Y,Ling M,Zhang L,Jiang S,Sha Y,Zhao R

Wed Oct 12 00:00:00 UTC 2016

Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.

The international journal of biochemistry & cell biology

Yang Y,Li X,Sun Q,He B,Jia Y,Cai D,Zhao R

Sat Oct 01 00:00:00 UTC 2016

Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.

The international journal of biochemistry & cell biology

Yang Y,Li X,Sun Q,He B,Jia Y,Cai D,Zhao R

Sat Oct 01 00:00:00 UTC 2016

Maternal Betaine Supplementation throughout Gestation and Lactation Modifies Hepatic Cholesterol Metabolic Genes in Weaning Piglets via AMPK/LXR-Mediated Pathway and Histone Modification.

Nutrients

Cai D,Yuan M,Liu H,Pan S,Ma W,Hong J,Zhao R

Tue Oct 18 00:00:00 UTC 2016

Maternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets.

Journal of agricultural and food chemistry

Jia Y,Song H,Gao G,Cai D,Yang X,Zhao R

Wed Nov 25 00:00:00 UTC 2015

Maternal Betaine Supplementation during Gestation Enhances Expression of mtDNA-Encoded Genes through D-Loop DNA Hypomethylation in the Skeletal Muscle of Newborn Piglets.

Journal of agricultural and food chemistry

Jia Y,Song H,Gao G,Cai D,Yang X,Zhao R

Wed Nov 25 00:00:00 UTC 2015

Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.

European journal of nutrition

Li X,Sun Q,Li X,Cai D,Sui S,Jia Y,Song H,Zhao R

Thu Oct 01 00:00:00 UTC 2015

Dietary betaine supplementation to gestational sows enhances hippocampal IGF2 expression in newborn piglets with modified DNA methylation of the differentially methylated regions.

European journal of nutrition

Li X,Sun Q,Li X,Cai D,Sui S,Jia Y,Song H,Zhao R

Thu Oct 01 00:00:00 UTC 2015

In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks.

PloS one

Hu Y,Sun Q,Li X,Wang M,Cai D,Li X,Zhao R

Thu Mar 31 00:00:00 UTC 2016

In Ovo injection of betaine affects hepatic cholesterol metabolism through epigenetic gene regulation in newly hatched chicks.

PloS one

Hu Y,Sun Q,Li X,Wang M,Cai D,Li X,Zhao R

Thu Mar 31 00:00:00 UTC 2016

Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.

PloS one

Cai D,Jia Y,Song H,Sui S,Lu J,Jiang Z,Zhao R

Thu Nov 12 00:00:00 UTC 2015

Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.

PloS one

Cai D,Jia Y,Song H,Sui S,Lu J,Jiang Z,Zhao R

Thu Nov 12 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: adenosylhomocysteinase-like 1; AdoHcyase 2; DC-expressed AHCY-like molecule; dendritic cell expressed AHCY-like protein; inositol 1,4,5-trisphosphate receptor-binding protein; IP(3)Rs binding protein released with IP(3); IP3R binding protein released with inositol 1,4,5-trisphosphate; IP3R-binding protein released with inositol 1,4,5-trisphosphate; IRBIT; protein phosphatase 1, regulatory subunit 78; Putative adenosylhomocysteinase 2; s adenosylhomocysteine hydrolase; S-adenosyl homocysteine hydrolase homolog; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase, related sequence 3; S-adenosylhomocysteine hydrolase-like 1; S-adenosylhomocysteine hydrolase-like protein 1

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Gene Aliases: 1110034F20Rik; AA409031; AA414901; Ahcy-rs3; AHCYL1; DCAL; IRBIT; PPP1R78; PRO0233; XPVKONA

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UniProt ID: (Human) O43865, (Rat) B5DFN2, (Mouse) Q80SW1

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Entrez Gene ID: (Human) 10768, (Rat) 362013, (Mouse) 229709

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Function(s)

RNA binding adenosylhomocysteinase activity protein binding hydrolase activity

Process(es)

mRNA polyadenylation protein export from nucleus one-carbon metabolic process positive regulation of sodium ion transport regulation of mRNA 3'-end processing regulation of ion transmembrane transporter activity S-adenosylmethionine cycle regulation of anion transport biological_process angiotensin-activated signaling pathway epithelial fluid transport response to calcium ion regulation of cardiac conduction

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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AHCYL1 Polyclonal Antibody

AHCYL1 Antibody (10658-3-AP) in ICC/IF

Product Details

10658-3-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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