Proteintech

AHR Monoclonal Antibody (2D1F9), CoraLite® 594

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CL594-67785

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

0.4 µg/1x10^6 cell suspension
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

2D1F9

Immunogen

Recombinant protein
View immunogen

Conjugate

CoraLite® 594 CoraLite® 594 CoraLite® 594

Excitation/Emission Max

593/614 nm

Form

Liquid

Purification

Protein A

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: PIPAEGIKSN PSKRHRDRLN TELDRLASLL PFPQDVINKL DKLSVLRLSV SYLRAKSFFD VALKSSPTER NGGQDNCRAA NFREGLNLQE GEFLLQALNG FVLVVTTDAL VFYASSTIQD YLGFQQSDVI HQSVYELIHT EDRAEFQRQL HWALNPSQCT ESGQGIEEAT GLPQTVVCYN PDQIPPENSP LMERCFICRL RCLLDNSSGF LAMNFQGKLK YLHGQKKKGK DGSILPPQLA LFAIATPLQP PSILEIRTKN FIFRTKHKLD FTPIGC

Target Information

AHR (Ah Receptor) belongs to a family of proteins comprised of its dimerization partner ARNT (HIF-1 Beta) and the Drosophila proteins PER and SIM. AHR contains an N-terminal sequence of approximately 200 amino acids termed the PAS domain. AHR, found in a variety of tissues, binds to a specific DNA enhancer sequence and initiates transcription of the mRNA for the cytochrome P-450 (CYPIA1) gene. The gene for AHR encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. AHR has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450, and its ligands included a variety of aromatic hydrocarbons. AHR is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for AHR. Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form, and this transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Ah receptor; AH-receptor; aromatic hydrocarbon receptor; Aryl hydrocarbon receptor; bHLHe76; Class E basic helix-loop-helix protein 76; dioxin receptor

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Gene Aliases: Ah; Ahh; AHR; Ahre; BHLHE76; In

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UniProt ID: (Human) P35869, (Mouse) P30561

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Entrez Gene ID: (Human) 196, (Mouse) 11622, (Rat) 25690

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Function(s)
DNA binding transcription factor activity, sequence-specific DNA binding aryl hydrocarbon receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding transcription factor binding enhancer binding transcription regulatory region DNA binding protein heterodimerization activity protein dimerization activity Hsp90 protein binding E-box binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding signal transducer activity sequence-specific DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis ovarian follicle development blood vessel development patterning of blood vessels B cell homeostasis liver development B-1 B cell homeostasis blood vessel remodeling lymphocyte homeostasis immune system process negative regulation of systemic arterial blood pressure cardiac left ventricle morphogenesis circumferential growth involved in left ventricle morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter xenobiotic metabolic process response to stress cell cycle signal transduction blood circulation regulation of blood pressure response to xenobiotic stimulus response to toxic substance regulation of gene expression response to organic cyclic compound B cell differentiation intracellular receptor signaling pathway prostate gland development regulation of B cell proliferation circadian regulation of gene expression embryonic hemopoiesis post-embryonic hemopoiesis camera-type eye development T cell homeostasis positive regulation of cell size negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of RNA polymerase II transcriptional preinitiation complex assembly negative regulation of vasoconstriction positive regulation of growth rhythmic process blood vessel morphogenesis spleen development reproductive structure development gland development smooth muscle tissue development regulation of blood vessel size regulation of heart growth negative regulation of necrotic cell death venous blood vessel development kidney morphogenesis common bile duct development cellular response to cAMP glomerulus morphogenesis apoptotic process response to estradiol positive regulation of transcription from RNA polymerase II promoter cellular response to glucocorticoid stimulus
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