Proteintech

AIDA Polyclonal Antibody

AIDA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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AIDA Antibody (23724-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse skeletal muscle tissue slide using 23724-1-AP ( AIDA antibody) at dilution of 1:100 (under 10x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

AIDA Antibody in Immunoprecipitation (IP)

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Product Details

23724-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

AIDA Fusion Protein Ag20588 (1-306 aa encoded by BC015535)

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSEVTRSLL QRWGASFRRG ADFDSWGQLV EAIDEYQILA RHLQKEAQAQ HNNSEFTEEQ KKTIGKIATC LELRSAALQS TQSQEEFKLE DLKKLEPILK NILTYNKEFP FDVQPVPLRR ILAPGEEENL EFEEDEEEGG AGAGSPDSFP ARVPGTLLPR LPSEPGMTLL TIRIEKIGLK DAGQCIDPYI TVSVKDLNGI DLTPVQDTPV ASRKEDTYVH FNVDIELQKH VEKLTKGAAI FFEFKHYKPK KRFTSTKCFA FMEMDEIKPG PIVIELYKKP TDFKRKKLQL LTKKPLYLHL HQTLHKE (1-306 aa encoded by BC015535)

Target Information

AIDA acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1.

Nature cell biology

Shi M,Huang XY,Ren XY,Wei XY,Ma Y,Lin ZZ,Liu DT,Song L,Zhao TJ,Li G,Yao L,Zhu M,Zhang C,Xie C,Wu Y,Wu HM,Fan LP,Ou J,Zhan YH,Lin SY,Lin SC

Mon Mar 01 00:00:00 UTC 2021

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

Cell metabolism

Luo H,Jiang M,Lian G,Liu Q,Shi M,Li TY,Song L,Ye J,He Y,Yao L,Zhang C,Lin ZZ,Zhang CS,Zhao TJ,Jia WP,Li P,Lin SY,Lin SC

Tue Apr 03 00:00:00 UTC 2018

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

Cell metabolism

Luo H,Jiang M,Lian G,Liu Q,Shi M,Li TY,Song L,Ye J,He Y,Yao L,Zhang C,Lin ZZ,Zhang CS,Zhao TJ,Jia WP,Li P,Lin SY,Lin SC

Tue Apr 03 00:00:00 UTC 2018

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

Cell metabolism

Luo H,Jiang M,Lian G,Liu Q,Shi M,Li TY,Song L,Ye J,He Y,Yao L,Zhang C,Lin ZZ,Zhang CS,Zhao TJ,Jia WP,Li P,Lin SY,Lin SC

Tue Apr 03 00:00:00 UTC 2018

AIDA Selectively Mediates Downregulation of Fat Synthesis Enzymes by ERAD to Retard Intestinal Fat Absorption and Prevent Obesity.

Cell metabolism

Luo H,Jiang M,Lian G,Liu Q,Shi M,Li TY,Song L,Ye J,He Y,Yao L,Zhang C,Lin ZZ,Zhang CS,Zhao TJ,Jia WP,Li P,Lin SY,Lin SC

Tue Apr 03 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: Axin interaction partner and dorsalization antagonist; Axin interactor, dorsalization-associated protein

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Gene Aliases: 2610208M17Rik; AIDA; BC004835; C1orf80

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UniProt ID: (Human) Q96BJ3, (Mouse) Q8C4Q6

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Entrez Gene ID: (Human) 64853, (Mouse) 108909

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Function(s)

protein binding protein domain specific binding phosphatidylinositol binding

Process(es)

multicellular organism development dorsal/ventral pattern formation negative regulation of Wnt signaling pathway regulation of protein homodimerization activity negative regulation of JUN kinase activity negative regulation of JNK cascade determination of ventral identity negative regulation of determination of dorsal identity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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AIDA Polyclonal Antibody

AIDA Antibody (23724-1-AP) in IHC (P)

Product Details

23724-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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