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Product Details
22517-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AIRE Fusion Protein Ag18249 (96-348 aa encoded by BC137270)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QKNEDECAV CRDGGELICC DGCPRAFHLA CLSPPLREIP SGTWRCSSCL QATVQEVQPR AEEPRPQEPP VETPLPPGLR SAGEEVRGPP GEPLAGMDTT LVYKHLPAPP SAAPLPGLDS SALHPLLCVG PEGQQNLAPG ARCGVCGDGT DVLRCTHCAA AFHWRCHFPA GTSRPGTGLR CRSCSGDVTP APVEGVLAPS PARLAPGPAK DDTASHEPAL HRDDLESLLS EHTFDGILQW AIQSMARPAA PFPS (96-348 aa encoded by BC137270)
Target Information
AIRE is a transcriptional regulator protein that binds to DNA as a dimer and tetramer, but not as a monomer, and may be involved in the regulation of gene expression. A nuclear protein, AIRE is a 545 amino acid protein with an HSR domain, two PHD type zinc fingers, and a SAND domain, and may be present in soluble high-molecular-weight complexes. It may form homodimer, homotetramer and also nuclear bodies and interacts with the transcriptional coactivator CBP and CREBBP. Three isoforms of AIRE are reported and one of them is predicted to be a candidate for nuclear-mediated decay (NMD). AIRE is involved in immune regulation and is known to mediate E3 ubiquitin ligase activity. Defects in AIRE are responsible for the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AIRE protein; APECED protein; APECED protein homolog; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; Autoimmune regulator; autoimmune regulator AIRE1a; OTTHUMP00000109529
Gene Aliases: AIRE; AIRE1; APECED; APS1; APSI; PGA1
UniProt ID: (Human) O43918, (Mouse) Q9Z0E3
Entrez Gene ID: (Human) 326, (Mouse) 11634
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription cofactor activity
protein binding
zinc ion binding
histone binding
identical protein binding
transcription regulatory region DNA binding
translation regulator activity
DNA binding
metal ion binding
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
regulation of translation
immune response
humoral immune response
negative thymic T cell selection
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
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