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AKR1C2 Antibody (PA5-97445) in WB
Western Blot analysis of AKR1C2 using a AKR1C2 Polyclonal antibody (Product # PA5-97445) at a concentration of 14 µg/mL. Lane 1: HepG2 whole cell lysate. Lane 2: MCF-7 whole cell lysate. Lane 3: Hela whole cell lysate. Lane 4: Rat liver tissue. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:10,000 dilution. Observed band size: 37 kDa.
Product Details
PA5-97445
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Aldo-keto reductase family 1 member C2 protein (1-323AA)
Conjugate
Form
Liquid
Concentration
3.5 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2812062
Target Information
DD1 is also designated AKR1C1, DDH or DDH1, while DD2 also can be designated AKR1C2, dDD, BABP or DDH2. AKR1C3 and 3 alpha-HSD are alternate designations for human DD3 (which is referred to as AKR1C18 in rodents), while DD4 also can be called AKR1C4, CD, CHDR or AKR1C6 (in rodents). DD1 and DD2 are 20 alpha-HSDs, whereas DD3 and DD4 are the 3 alpha- HSDs. The multiple human cytosolic dihydrodiol dehydrogenases are involved in the metabolism of xenobiotics, such as polycyclic aromatic hydrocarbons, pesticides and steroid hormones, and are responsible for the reduction of ketone-containing drugs by using NADH or NADPH as a cofactor. The 20 alpha- HSD catalyzes the reaction of Progesterone to the inactive form 20 alpha-hydroxyprogesterone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 3 alpha-HSD3; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-HSD3; 3-alpha-hydroxysteroid dehydrogenase; Aldo-keto reductase family 1 member C2; Aldo-keto reductase family 1 member C21; aldo-keto reductase family 1, member C21; Chlordecone reductase homolog HAKRD; DD-2; DD/BABP; Dihydrodiol dehydrogenase 2; dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III; Dihydrodiol dehydrogenase/bile acid-binding protein; HSD3-3 alpha; HSD3-alpha3; pseudo-chlordecone reductase; testicular 17,20-desmolase deficiency; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II dihydrodiol dehydrogenase; Type III 3-alpha-hydroxysteroid dehydrogenase
Gene Aliases: AKR1C-pseudo; AKR1C2; Akr1c21; BABP; DD; DD-2; DD/BABP; DD2; DDH2; HAKRD; HBAB; MCDR2; SRXY8; TDD
UniProt ID: (Human) P52895, (Rat) Q6AYQ2
Entrez Gene ID: (Human) 1646, (Rat) 291283
alditol:NADP+ 1-oxidoreductase activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
phenanthrene 9,10-monooxygenase activity
carboxylic acid binding
bile acid binding
ketosteroid monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
oxidoreductase activity
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
androsterone dehydrogenase activity
prostaglandin metabolic process
G-protein coupled receptor signaling pathway
digestion
steroid metabolic process
positive regulation of cell proliferation
epithelial cell differentiation
progesterone metabolic process
daunorubicin metabolic process
doxorubicin metabolic process
positive regulation of protein kinase B signaling
oxidation-reduction process
cellular response to jasmonic acid stimulus
cellular response to prostaglandin D stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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