Invitrogen

AKT2 Monoclonal Antibody (1B6)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-15593

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

1:200-1:1,000
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Non-human primate, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

1B6

Immunogen

Purified recombinant fragment of human AKT2 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10974323

Product Specific Information

MA5-15593 targets AKT2 in indirect ELISA, IF, IHC, and WB applications and shows reactivity with Human, Non-human primate, and Rat samples.

The MA5-15593 immunogen is purified recombinant fragment of human AKT2 expressed in E. Coli.

MA5-15593 detects AKT2 which has a predicted molecular weight of approximately 60kDa.

Target Information

AKT2 is a phosphoinositide-dependent serine/threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone. Akt is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AKT2 kinase; murine thymoma viral (v-akt) homolog-2; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; putative v-akt murine thymoma viral oncoprotein 2; RAC protein kinase beta; RAC protein kinase beta RAC-PK beta; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; v-akt murine thymoma viral oncogene homolog 2

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Gene Aliases: AKT2; HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA

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UniProt ID: (Human) P31751, (Rat) P47197

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Entrez Gene ID: (Human) 208, (Rat) 25233

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Function(s)
protein serine/threonine kinase activity protein kinase C binding protein binding ATP binding protein kinase activity
Process(es)
positive regulation of protein phosphorylation glycogen biosynthetic process glucose metabolic process regulation of translation protein phosphorylation response to osmotic stress multicellular organism development insulin receptor signaling pathway carbohydrate transport positive regulation of signal transduction positive regulation of gene expression negative regulation of plasma membrane long-chain fatty acid transport positive regulation of sodium ion transport positive regulation of glucose metabolic process response to muscle activity positive regulation of cell migration positive regulation of vesicle fusion response to nutrient levels positive regulation of fatty acid beta-oxidation peripheral nervous system myelin maintenance response to insulin cellular response to insulin stimulus cellular response to hormone stimulus negative regulation of RNA splicing positive regulation of peptidyl-serine phosphorylation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase B signaling positive regulation of nitric oxide biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import positive regulation of positive chemotaxis intracellular protein transmembrane transport cellular response to organic cyclic compound protein localization to plasma membrane positive regulation of protein targeting to membrane positive regulation of cell motility positive regulation of glucose import in response to insulin stimulus cellular protein modification process apoptotic process signal transduction peptidyl-serine phosphorylation regulation of cell migration intracellular signal transduction fat cell differentiation mammary gland epithelial cell differentiation regulation of cell cycle arrest activation of GTPase activity
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