Invitrogen

AKT2 Monoclonal Antibody (4H7)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA1-034

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunocytochemistry (ICC/IF)

1:10-1:100
-

Immunoprecipitation (IP)

2 µg
-

ChIP assay (ChIP)

1-3 µL
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4H7

Immunogen

Full length human recombinant protein of human AKT2 (NP_001617) produced in HEK293T cell.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS with 1mg/mL BSA, 30% glycerol

Contains

0.05% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11153437

Target Information

AKT2 is a phosphoinositide-dependent serine/threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone. Akt is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AKT2 kinase; murine thymoma viral (v-akt) homolog-2; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; putative v-akt murine thymoma viral oncoprotein 2; RAC protein kinase beta; RAC protein kinase beta RAC-PK beta; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; v-akt murine thymoma viral oncogene homolog 2

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Gene Aliases: 2410016A19Rik; AKT2; AW554154; HIHGHH; PKB; PKBB; PKBBETA; PRKBB; RAC-BETA

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UniProt ID: (Human) P31751, (Rat) P47197, (Mouse) Q60823

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Entrez Gene ID: (Human) 208, (Rat) 25233, (Mouse) 11652

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Function(s)
protein serine/threonine kinase activity protein kinase C binding protein binding ATP binding protein kinase activity nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
positive regulation of protein phosphorylation glycogen biosynthetic process glucose metabolic process regulation of translation protein phosphorylation response to osmotic stress multicellular organism development insulin receptor signaling pathway carbohydrate transport positive regulation of signal transduction positive regulation of gene expression negative regulation of plasma membrane long-chain fatty acid transport positive regulation of sodium ion transport positive regulation of glucose metabolic process response to muscle activity positive regulation of cell migration positive regulation of vesicle fusion response to nutrient levels positive regulation of fatty acid beta-oxidation peripheral nervous system myelin maintenance response to insulin cellular response to insulin stimulus cellular response to hormone stimulus negative regulation of RNA splicing positive regulation of peptidyl-serine phosphorylation negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein kinase B signaling positive regulation of nitric oxide biosynthetic process positive regulation of glycogen biosynthetic process positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import positive regulation of positive chemotaxis intracellular protein transmembrane transport cellular response to organic cyclic compound protein localization to plasma membrane positive regulation of protein targeting to membrane positive regulation of cell motility positive regulation of glucose import in response to insulin stimulus carbohydrate metabolic process glycogen metabolic process transport apoptotic process phosphorylation activation of GTPase activity cellular protein modification process signal transduction peptidyl-serine phosphorylation regulation of cell migration intracellular signal transduction fat cell differentiation mammary gland epithelial cell differentiation regulation of cell cycle arrest
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