Proteintech

AKT3 Polyclonal Antibody

AKT3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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AKT3 Antibody (21641-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using (Product # 21641-1-AP) (AKT3 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

21641-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

AKT3 Fusion Protein Ag16298 (95-155 aa encoded by BC121154)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.16 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: REEWTEAIQ AVADRLQRQE EERMNCSPTS QIDNIGEEEM DASTTHHKRK TMNDFDYLKL LG (95-155 aa encoded by BC121154)

Target Information

AKT3 (PKB gamma) has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). It is involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, glycogen synthesis and glucose uptake. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

circHIPK3 regulates cell proliferation and migration by sponging microRNA-124 and regulating serine/threonine kinase 3 expression in esophageal squamous cell carcinoma.

Bioengineered

Yao D,Lin S,Chen S,Wang Z

Fri Apr 01 00:00:00 UTC 2022

NEK7 promotes gastric cancer progression as a cell proliferation regulator.

Cancer cell international

Li YK,Zhu XR,Zhan Y,Yuan WZ,Jin WL

Sat Aug 21 00:00:00 UTC 2021

Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy.

Clinical epigenetics

Wang C,Sun Y,Yin X,Feng R,Feng R,Xu M,Liang K,Zhao R,Gu G,Jiang X,Su P,Zhang X,Liu J

Sat Dec 04 00:00:00 UTC 2021

Effects of CDKN2B-AS1 on cellular proliferation, invasion and AKT3 expression are attenuated by miR-424-5p in a model of ovarian endometriosis.

Reproductive biomedicine online

Wang S,Yi M,Zhang X,Zhang T,Jiang L,Cao L,Zhou Y,Fang X

Tue Jun 01 00:00:00 UTC 2021

YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition.

Experimental hematology & oncology

Luo X,Cao M,Gao F,He X

Fri Jun 04 00:00:00 UTC 2021

Long Non-coding RNA AK025387 Promotes Cell Migration and Invasion of Gastric Cancer.

Frontiers in oncology

Sun YY,Zhang H,Ma RR,Zhang GH,Tian YR,Liu L,Liu L,Gao P

Mon Sep 28 00:00:00 UTC 2020

EGR1 interacts with DNMT3L to inhibit the transcription of miR-195 and plays an anti-apoptotic role in the development of gastric cancer.

Journal of cellular and molecular medicine

Yang Y,Wu F,Zhang J,Sun R,Li F,Li Y,Chang S,Wang L,Wang X,Liu L,Huang C

Fri Nov 01 00:00:00 UTC 2019

MiR-384 inhibits the proliferation of colorectal cancer by targeting AKT3.

Cancer cell international

Wang YX,Zhu HF,Zhang ZY,Ren F,Hu YH

Mon Mar 21 00:00:00 UTC 2022

MiR-384 inhibits the proliferation of colorectal cancer by targeting AKT3.

Cancer cell international

Wang YX,Zhu HF,Zhang ZY,Ren F,Hu YH

Mon Mar 21 00:00:00 UTC 2022

Role of BMI1 in epithelial ovarian cancer: investigated via the CRISPR/Cas9 system and RNA sequencing.

Journal of ovarian research

Zhao Q,Qian Q,Cao D,Yang J,Gui T,Shen K

Mon Apr 23 00:00:00 UTC 2018

Role of BMI1 in epithelial ovarian cancer: investigated via the CRISPR/Cas9 system and RNA sequencing.

Journal of ovarian research

Zhao Q,Qian Q,Cao D,Yang J,Gui T,Shen K

Mon Apr 23 00:00:00 UTC 2018

MicroRNA-150 negatively regulates the function of CD4(+) T cells through AKT3/Bim signaling pathway.

Cellular immunology

Sang W,Sun C,Zhang C,Zhang D,Wang Y,Xu L,Zhang Z,Wei X,Pan B,Yan D,Zhu F,Yan Z,Cao J,Loughran TP,Xu K

Mon Jun 26 00:00:00 UTC 2017

MicroRNA-150 negatively regulates the function of CD4(+) T cells through AKT3/Bim signaling pathway.

Cellular immunology

Sang W,Sun C,Zhang C,Zhang D,Wang Y,Xu L,Zhang Z,Wei X,Pan B,Yan D,Zhu F,Yan Z,Cao J,Loughran TP,Xu K

Mon Jun 26 00:00:00 UTC 2017

MYO6 knockdown inhibits the growth and induces the apoptosis of prostate cancer cells by decreasing the phosphorylation of ERK1/2 and PRAS40.

Oncology reports

Wang D,Zhu L,Liao M,Zeng T,Zhuo W,Yang S,Wu W

Thu Sep 01 00:00:00 UTC 2016

MYO6 knockdown inhibits the growth and induces the apoptosis of prostate cancer cells by decreasing the phosphorylation of ERK1/2 and PRAS40.

Oncology reports

Wang D,Zhu L,Liao M,Zeng T,Zhuo W,Yang S,Wu W

Thu Sep 01 00:00:00 UTC 2016

Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.

Scientific reports

Liu J,Huang W,Ren C,Wen Q,Liu W,Yang X,Wang L,Zhu B,Zeng L,Feng X,Zhang C,Chen H,Jia W,Zhang L,Xia X,Chen Y

Fri Jul 24 00:00:00 UTC 2015

Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.

Scientific reports

Liu J,Huang W,Ren C,Wen Q,Liu W,Yang X,Wang L,Zhu B,Zeng L,Feng X,Zhang C,Chen H,Jia W,Zhang L,Xia X,Chen Y

Fri Jul 24 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: AKT3 kinase; DKFZP434N0250; PKB gamma; Protein kinase Akt-3; Protein kinase B gamma; protein kinase B, gamma; RAC-gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; STK-2; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene 3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

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Gene Aliases: AI851531; AKT3; D930002M15Rik; MPPH; MPPH2; Nmf350; PKB-GAMMA; PKBG; PRKBG; RAC-gamma; RAC-PK-gamma; STK-2

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UniProt ID: (Human) Q9Y243, (Rat) Q63484, (Mouse) Q9WUA6

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Entrez Gene ID: (Human) 10000, (Rat) 29414, (Mouse) 23797

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Function(s)

protein kinase activity protein serine/threonine kinase activity protein binding ATP binding protein kinase C binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

Process(es)

mitochondrial genome maintenance protein phosphorylation signal transduction peptidyl-serine phosphorylation intracellular signal transduction positive regulation of sodium ion transport cellular response to insulin stimulus phosphorylation peptidyl-threonine phosphorylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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AKT3 Polyclonal Antibody

AKT3 Antibody (21641-1-AP) in IHC (P)

Product Details

21641-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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