Proteintech

ALDH3A1 Polyclonal Antibody

ALDH3A1 Antibody in Immunocytochemistry (ICC/IF)

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ALDH3A1 Antibody (15578-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HEK-293T cells using ALDH3A1 antibody (Product # 15578-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

ALDH3A1 Antibody in Flow Cytometry (Flow)

ALDH3A1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15578-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

Assay-dependent

View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

View 7 publications 7 publications

Flow Cytometry (Flow)

Assay-dependent

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ALDH3A1 Fusion Protein Ag7977 (105-453 aa encoded by BC004370)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LGVVLVIGT WNYPFNLTIQ PMVGAIAAGN AVVLKPSELS ENMASLLATI IPQYLDKDLY PVINGGVPET TELLKERFDH ILYTGSTGVG KIIMTAAAKH LTPVTLELGG KSPCYVDKNC DLDVACRRIA WGKFMNSGQT CVAPDYILCD PSIQNQIVEK LKKSLKEFYG EDAKKSRDYG RIISARHFQR VMGLIEGQKV AYGGTGDAAT RYIAPTILTD VDPQSPVMQE EIFGPVLPIV CVRSLEEAIQ FINQREKPLA LYMFSSNDKV IKKMIAETSS GGVAANDVIV HITLHSLPFG GVGNSGMGSY HGKKSFETFS HRRSCLVRPL MNDEGLKVRY PPSPAKMTQH (105-453 aa encoded by BC004370)

Target Information

Aldh3A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldh3A1 is highly expressed in stomach and even more strongly in cornea, representing between 5 to 50% of the water soluble protein fraction in mammalian corneas. It is thought that Aldh3A1 acts to protect the cornea from UV-induced oxidative stress by not only detoxification of reactive aldehydes by also through the direct absorption of UV energy. However, corneas from Aldh3A1-null mice are indistinguishable from those from wild-type mice; mice lacking both Aldh3A1 and Aldh1A1 showed increased cataract formation following UVB exposure, suggesting that Aldh1A1 may be able to compensate for the loss of Aldh3A1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Regulation of the Keratocyte Phenotype and Cell Behavior Derived from Human Induced Pluripotent Stem Cells by Substrate Stiffness.

ACS biomaterials science & engineering

Zhang L,Liang L,Su T,Guo Y,Yu Q,Zhu D,Cui Z,Zhang J,Chen J

Mon Feb 13 00:00:00 UTC 2023

Regulation of the Keratocyte Phenotype and Cell Behavior Derived from Human Induced Pluripotent Stem Cells by Substrate Stiffness.

ACS biomaterials science & engineering

Zhang L,Liang L,Su T,Guo Y,Yu Q,Zhu D,Cui Z,Zhang J,Chen J

Mon Feb 13 00:00:00 UTC 2023

Stiffness-dependent dynamic effect of inflammation on keratocyte phenotype and differentiation.

Biomedical materials (Bristol, England)

Chen J,Mo Q,Sheng R,Long Q,Chen Z,Liu C,Zhang A,Luo Y,Liu J,Zhang W

Thu Apr 27 00:00:00 UTC 2023

Hydroxycamptothecin and Substratum Stiffness Synergistically Regulate Fibrosis of Human Corneal Fibroblasts.

ACS biomaterials science & engineering

Chen J,Mo Q,Long Q,Sheng R,Chen Z,Luo Y,Liu C,Backman LJ,Zhang Y,Zhang W

Mon Feb 13 00:00:00 UTC 2023

Human Umbilical Mesenchymal Stem Cell Xenografts Repair UV-Induced Photokeratitis in a Rat Model.

Biomedicines

Fu YS,Chen PR,Yeh CC,Pan JY,Kuo WC,Tseng KW

Thu May 12 00:00:00 UTC 2022

Alpha-solanine Anti-tumor Effects in Non-small Cell Lung Cancer Through Regulating the Energy Metabolism Pathway.

Recent patents on anti-cancer drug discovery

Zou T,Gu L,Yang L,Wei J,Zhao Y,Shen J,Li M,Wu X,Du F,Chen Y,Ye Y,Xiao Z,Wu Z

Thu Jul 28 00:00:00 UTC 2022

Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.

Molecular cell

Fiore A,Zeitler L,Russier M,Groß A,Hiller MK,Parker JL,Stier L,Köcher T,Newstead S,Murray PJ

Thu Mar 03 00:00:00 UTC 2022

Lipid-derived electrophiles mediate the effects of chemotherapeutic topoisomerase I poisons.

Cell chemical biology

Flor A,Wolfgeher D,Li J,Hanakahi LA,Kron SJ

Thu Jun 17 00:00:00 UTC 2021

Lineage Contribution of PDGFRα-Expressing Cells in the Developing Mouse Eye.

BioMed research international

Zhuo D,Diao Y,Li X,Huang Y,Wang L

Thu Sep 23 00:00:00 UTC 2021

Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma.

Nature communications

Kong B,Chen Y,Liu R,Liu X,Liu C,Shao Z,Xiong L,Liu X,Sun W,Mi S

Wed Mar 18 00:00:00 UTC 2020

Exosomes carrying ALDOA and ALDH3A1 from irradiated lung cancer cells enhance migration and invasion of recipients by accelerating glycolysis.

Molecular and cellular biochemistry

Wang C,Xu J,Yuan D,Bai Y,Pan Y,Zhang J,Shao C

Mon Jun 01 00:00:00 UTC 2020

Sustained Release of TPCA-1 from Silk Fibroin Hydrogels Preserves Keratocyte Phenotype and Promotes Corneal Regeneration by Inhibiting Interleukin-1β Signaling.

Advanced healthcare materials

Zhang W,Chen J,Qu M,Backman LJ,Zhang A,Liu H,Zhang X,Zhou Q,Danielson P

Tue Sep 01 00:00:00 UTC 2020

A core-skirt designed artificial cornea with orthogonal microfiber grid scaffold.

Experimental eye research

Wang J,Chen Y,Bai Y,Quan D,Wang Z,Xiong L,Shao Z,Sun W,Mi S

Mon Jun 01 00:00:00 UTC 2020

A cellular and proteomic approach to assess proteins extracted from cryopreserved human amnion in the cultivation of corneal stromal keratocytes for stromal cell therapy.

Eye and vision (London, England)

Fenner BJ,Yusoff NZBM,Fuest M,Zhou L,Bandeira F,Cajucom-Uy HY,Tan HK,Mehta JS,Yam GHF

Sun Apr 10 00:00:00 UTC 2022

Elucidation of the AGR2 Interactome in Esophageal Adenocarcinoma Cells Identifies a Redox-Sensitive Chaperone Hub for the Quality Control of MUC-5AC.

Antioxidants & redox signaling

Worfolk JC,Bell S,Simpson LD,Carne NA,Francis SL,Engelbertsen V,Brown AP,Walker J,Viswanath YK,Benham AM

Wed Nov 20 00:00:00 UTC 2019

Safety and Feasibility of Intrastromal Injection of Cultivated Human Corneal Stromal Keratocytes as Cell-Based Therapy for Corneal Opacities.