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ALDH4A1 Polyclonal Antibody

ALDH4A1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ALDH4A1 Antibody (11604-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 11604-1-AP) (ALDH4A1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

ALDH4A1 Antibody in Immunoprecipitation (IP)

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Product Details

11604-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2400

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ALDH4A1 Fusion Protein Ag2147 (246-563 aa encoded by BC023600)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YRILREAGL PPNIIQFVPA DGPLFGDTVT SSEHLCGINF TGSVPTFKHL WKQVAQNLDR FHTFPRLAGE CGGKNFHFVH RSADVESVVS GTLRSAFEYG GQKCSACSRL YVPHSLWPQI KGRLLEEHSR IKVGDPAEDF GTFFSAVIDA KSFARIKKWL EHARSSPSLT ILAGGKCDDS VGYFVEPCIV ESKDPQEPIM KEEIFGPVLS VYVYPDDKYK ETLQLVDSTT SYGLTGAVFS QDKDVVQEAT KVLRNAAGNF YINDKSTGSI VGQQPFGGAR ASGTNDKPGG PHYILRWTSP QVIKETHKPL GDWSYAYMQ (246-563 aa encoded by BC023600)

Target Information

ALDH4A1 belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer.

Journal of experimental & clinical cancer research : CR

Liu C,Pan Z,Chen Q,Chen Z,Liu W,Wu L,Jiang M,Lin W,Zhang Y,Lin W,Zhou R,Zhao L

Wed Sep 22 00:00:00 UTC 2021

Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer.

Journal of experimental & clinical cancer research : CR

Liu C,Pan Z,Chen Q,Chen Z,Liu W,Wu L,Jiang M,Lin W,Zhang Y,Lin W,Zhou R,Zhao L

Wed Sep 22 00:00:00 UTC 2021

Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer.

Journal of experimental & clinical cancer research : CR

Liu C,Pan Z,Chen Q,Chen Z,Liu W,Wu L,Jiang M,Lin W,Zhang Y,Lin W,Zhou R,Zhao L

Wed Sep 22 00:00:00 UTC 2021

Pharmacological targeting PTK6 inhibits the JAK2/STAT3 sustained stemness and reverses chemoresistance of colorectal cancer.

Journal of experimental & clinical cancer research : CR

Liu C,Pan Z,Chen Q,Chen Z,Liu W,Wu L,Jiang M,Lin W,Zhang Y,Lin W,Zhou R,Zhao L

Wed Sep 22 00:00:00 UTC 2021

Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure.

Scientific reports

Jones B,Balasubramaniam M,Lebowitz JJ,Taylor A,Villalta F,Khoshbouei H,Grueter C,Grueter B,Dash C,Pandhare J

Thu Jan 14 00:00:00 UTC 2021

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.

Proceedings of the National Academy of Sciences of the United States of America

Liu W,Le A,Hancock C,Lane AN,Dang CV,Fan TW,Phang JM

Tue Jun 05 00:00:00 UTC 2012

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC.

Proceedings of the National Academy of Sciences of the United States of America

Liu W,Le A,Hancock C,Lane AN,Dang CV,Fan TW,Phang JM

Tue Jun 05 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: aldehyde dehydrogenase 4 family, member A1; Aldehyde dehydrogenase family 4 member A1; Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; L-glutamate gamma-semialdehyde dehydrogenase; mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase; P5C dehydrogenase; RP11-128M10.1

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Gene Aliases: A930035F14Rik; Ahd-1; Ahd1; ALDH4; ALDH4A1; Aldh5a1; E330022C09; P5CD; P5CDH; P5cdhl; P5cdhs; Ssdh1

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UniProt ID: (Human) P30038, (Mouse) Q8CHT0

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Entrez Gene ID: (Human) 8659, (Rat) 641316, (Mouse) 212647

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Function(s)

1-pyrroline-5-carboxylate dehydrogenase activity aldehyde dehydrogenase (NAD) activity electron carrier activity identical protein binding structural molecule activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor oxidoreductase activity

Process(es)

glutamate biosynthetic process proline biosynthetic process proline catabolic process to glutamate oxidation-reduction process proline metabolic process metabolic process proline catabolic process 4-hydroxyproline catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ALDH4A1 Polyclonal Antibody

ALDH4A1 Antibody (11604-1-AP) in IHC (P)

Product Details

11604-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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