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Proteintech
ALKBH4 Polyclonal Antibody
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Product Details
19882-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ALKBH4 Fusion Protein Ag8041 (1-302 aa encoded by BC002820)
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAAAAAETP EVLRECGCKG IRTCLICERQ RGSDPPWELP PAKTYRFIYC SDTGWAVGTE ESDFEGWAFP FPGVMLIEDF VTREEEAELV RLMDRDPWKL SQSGRRKQDY GPKVNFRKQK LKTEGFCGLP SFSREVVRRM GLYPGLEGFR PVEQCNLDYC PERGSAIDPH LDDAWLWGER LVSLNLLSPT VLSMCREAPG SLLLCSAPSA APEALVDSVI APSRSVLCQE VEVAIPLPAR SLLVLTGAAR HQWKHAIHRR HIEARRVCVT FRELSAEFGP GGRQQELGQE LLRIALSFQG RPV (1-302 aa encoded by BC002820)
Target Information
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alkB homolog 4, lysine demthylase; alkB, alkylation repair homolog 4; Alkylated DNA repair protein alkB homolog 4; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; DNA N6-methyl adenine demethylase ALKBH4; Lysine-specific demethylase ALKBH4; probable alpha-ketoglutarate-dependent dioxygenase ABH4
Gene Aliases: 2010004B12Rik; ABH4; Abj4; ALKBH4; RGD1308608
UniProt ID: (Human) Q9NXW9, (Mouse) Q9D8F1
Entrez Gene ID: (Human) 54784, (Rat) 288587, (Mouse) 72041
actin binding
protein binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
demethylase activity
metal ion binding
sulfonate dioxygenase activity
oxidoreductase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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