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Invitrogen
ALOX15B Polyclonal Antibody
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FIGURE: 1 / 4
ALOX15B Antibody (PA5-97456) in ICC/IF
Immunofluorescent analysis of ALOX15B in A549 cells using a ALOX15B polyclonal antibody (Product # PA5-97456) at a dilution of 1:166. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG(H+L). Cells were counter-stained with DAPI.
Product Details
PA5-97456
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Arachidonate 15-lipoxygenase B protein (1-676AA)
Conjugate
Form
Liquid
Concentration
4 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
RRID
AB_2812073
Target Information
ALOX15B encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 15-lipoxygenase 2; 15-LOX-2; 15-LOX-B; 15S-lipoxygenase; arachidonate 15-lipoxygenase 2; Arachidonate 15-lipoxygenase B; Arachidonate 15-lipoxygenase type II; arachidonate 15-lipoxygenase, second type; arachidonate omega(6) lipoxygenase; Linoleate 13-lipoxygenase 15-LOb; Polyunsaturated fatty acid lipoxygenase ALOX15B
Gene Aliases: 15-LOX-2; ALOX15B
UniProt ID: (Human) O15296
Entrez Gene ID: (Human) 247
lipid metabolic process
apoptotic process
negative regulation of cell proliferation
positive regulation of macrophage derived foam cell differentiation
arachidonic acid metabolic process
lipoxygenase pathway
negative regulation of cell migration
prostate gland development
regulation of epithelial cell differentiation
positive regulation of peroxisome proliferator activated receptor signaling pathway
linoleic acid metabolic process
positive regulation of keratinocyte differentiation
negative regulation of cell cycle
negative regulation of growth
hepoxilin biosynthetic process
oxidation-reduction process
positive regulation of chemokine secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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