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ALPK1 Polyclonal Antibody

ALPK1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ALPK1 Antibody (19107-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using (Product # 19107-1-AP) (ALPK1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

19107-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ALPK1 Fusion Protein Ag5320 (1-347 aa encoded by BC060780)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MNNQKVVAV LLQECKQVLD QLLLEAPDVS EEDKSEDQRC RALLPSELRT LIQEAKEMKW PFVPEKWQYK QAVGPEDKTN LKDVIGAGLQ QLLASLRASI LARDCAAAAA IVFLVDRFLY GLDVSGKLLQ VAKGLHKLQP ATPIAPQVVI RQARISVNSG KLLKAEYILS SLISNNGATG TWLYRNESDK VLVQSVCIQI RGQILQKLGM WYEAAELIWA SIVGYLALPQ PDKKGLSTSL GILADIFVSM SKNDYEKFKN NPQINLSLLK EFDHHLLSAA EACKLAAAFS AYTPLFVLTA VNIRGTCLLS YSSSNDCPPE LKNLHLCEAK EAFEIGLLTK RDDEPVTG (1-347 aa encoded by BC060780)

Target Information

Unlike most eukaryotic kinases, alpha kinases, such as LAK, recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Liu X,Zhao J,Jiang H,Guo H,Li Y,Li H,Feng Y,Ke J,Long X

Sat Oct 01 00:00:00 UTC 2022

Neuroprotective effect of alpha-kinase 1 knockdown against cerebral ischemia through inhibition of the NF-κB pathway and neuroinflammation.

International immunopharmacology

Li JY,Zheng ZX,Liu L,Du O,Yu NW,Zou Y,Seong SY,Du JR

Thu Dec 01 00:00:00 UTC 2022

ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.

Journal of dental research

Liu X,Zhao J,Jiang H,Li H,Feng Y,Ke J,Long X

Tue Nov 01 00:00:00 UTC 2022

ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.

Journal of dental research

Liu X,Zhao J,Jiang H,Li H,Feng Y,Ke J,Long X

Tue Nov 01 00:00:00 UTC 2022

ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.

Journal of dental research

Liu X,Zhao J,Jiang H,Li H,Feng Y,Ke J,Long X

Tue Nov 01 00:00:00 UTC 2022

ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.

Journal of dental research

Liu X,Zhao J,Jiang H,Li H,Feng Y,Ke J,Long X

Tue Nov 01 00:00:00 UTC 2022

Alpk1 Sensitizes Pancreatic Beta Cells to Cytokine-Induced Apoptosis via Upregulating TNF-α Signaling Pathway.

Frontiers in immunology

Ding F,Luo X,Tu Y,Duan X,Liu J,Jia L,Zheng P

Mon Dec 20 00:00:00 UTC 2021

ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder.

Genetics in medicine : official journal of the American College of Medical Genetics

Williams LB,Javed A,Sabri A,Morgan DJ,Huff CD,Grigg JR,Heng XT,Khng AJ,Hollink IHIM,Morrison MA,Owen LA,Anderson K,Kinard K,Greenlees R,Novacic D,Nida Sen H,Zein WM,Rodgers GM,Vitale AT,Haider NB,Hillmer AM,Ng PC,Cheng A,Zheng L,Gillies MC,van Slegtenhorst M,van Hagen PM,Missotten TOAR,Farley GL,Polo M,Malatack J,Curtin J,Martin F,Arbuckle S,Alexander SI,Chircop M,Davila S,Digre KB,Jamieson RV,DeAngelis MM

Sun Sep 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: alpha-kinase 1; Alpha-protein kinase 1; Chromosome 4 kinase; lymphocyte alpha-kinase; Lymphocyte alpha-protein kinase

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Gene Aliases: 8430410J10Rik; ALPK1; KIAA1527; LAK

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UniProt ID: (Human) Q96QP1

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Entrez Gene ID: (Human) 80216, (Mouse) 71481

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Function(s)

protein serine/threonine kinase activity ATP binding molecular_function transmembrane receptor protein serine/threonine kinase activity 3-phosphoinositide-dependent protein kinase activity DNA-dependent protein kinase activity AMP-activated protein kinase activity cyclic nucleotide-dependent protein kinase activity eukaryotic translation initiation factor 2alpha kinase activity calcium-dependent protein kinase C activity receptor signaling protein serine/threonine kinase activity NF-kappaB-inducing kinase activity JUN kinase activity JUN kinase kinase kinase activity MAP kinase kinase activity MAP kinase kinase kinase activity ribosomal protein S6 kinase activity MAP kinase kinase kinase kinase activity JUN kinase kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups SAP kinase activity transmembrane receptor protein kinase activity cyclin-dependent protein kinase activating kinase activity GTP-dependent protein kinase activity

Process(es)

positive regulation of defense response to virus by host protein phosphorylation mitophagy in response to mitochondrial depolarization xenophagy phosphorylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ALPK1 Polyclonal Antibody

ALPK1 Antibody (19107-1-AP) in IHC (P)

Product Details

19107-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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