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Invitrogen
ALS2CR2 Polyclonal Antibody
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Product Details
PA5-20035
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to amino acids near the center of human ILPIP.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11152737
Product Specific Information
A suggested positive control is human brain tissue lysate.
PA5-20035 can be used with blocking peptide PEP-0154.
Target Information
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog; CALS-21; ILP-interacting protein; ILP-interacting protein homolog; ILP-interacting protein ILPIPA; MGC102916; polyploidy associated protein kinase; polyploidy associated protein kinase PAPK-A; Polyploidy-associated protein kinase; Pseudokinase ALS2CR2; STE20-related kinase adapter protein beta; STRAD beta
Gene Aliases: AA792893; ALS2CR2; B830008M19; CALS-21; D1Ucla2; ILPIP; ILPIPA; PAPK; PRO1038; RGD1559449; STRADB; Syradb
UniProt ID: (Human) Q9C0K7, (Mouse) Q8K4T3
Entrez Gene ID: (Human) 55437, (Mouse) 227154, (Rat) 501146
cell morphogenesis
protein phosphorylation
protein export from nucleus
cytoskeleton organization
cell cycle
JNK cascade
Rho protein signal transduction
regulation of mitotic cell cycle
cell migration
actin cytoskeleton organization
activation of protein kinase activity
regulation of MAPK cascade
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
cell cycle arrest
mitotic cell cycle
intracellular signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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