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Product Details
14076-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AMIGO2 Fusion Protein Ag5200 (30-399 aa encoded by BC047595)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TVTVGPGAS GVCPTACICA TDIVSCTNKN LSKVPGNLFR LIKRLDLSYN RIGLLDSEWI PVSFAKLNTL ILRHNNITSI STGSFSTTPN LKCLDLSSNK LKTVKNAVFQ ELKVLEVLLL YNNHISYLDP SAFGGLSQLQ KLYLSGNFLT QFPMDLYVGR FKLAELMFLD VSYNRIPSMP MHHINLVPGK QLRGIYLHGN PFVCDCSLYS LLVFWYRRHF SSVMDFKNDY TCRLWSDSRH SRQVLLLQDS FMNCSDSIIN GSFRALGFIH EAQVGERLMV HCDSKTGNAN TDFIWVGPDN RLLEPDKEME NFYVFHNGSL VIESPRFEDA GVYSCIAMNK QRLLNETVDV TINVSNFTVS RSHAHEAFNT A (30-399 aa encoded by BC047595)
Target Information
A novel primary response gene, Alivin 1 (ali1), is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human Ali1 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adhesion molecule with Ig-like domain 2; alivin 1; Alivin-1; AMIGO-2; AMIGO2; amigo2 {ECO:0000312|EMBL:AAO48951.1}; amphoterin induced gene 2; amphoterin induced gene and ORF 2; Amphoterin-induced protein 2; DEGA; differentially expressed in gastric adenocarcinoma; Differentially expressed in gastric adenocarcinomas; transmembrane protein AMIGO2
Gene Aliases: AI415330; ALI1; AMIGO-2; AMIGO2; AW208913; DEGA
UniProt ID: (Human) Q86SJ2, (Mouse) Q80ZD9, (Rat) Q7TNJ4
Entrez Gene ID: (Human) 347902, (Mouse) 105827, (Rat) 300186
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
negative regulation of apoptotic process
negative regulation of programmed cell death
positive regulation of synapse assembly
cell adhesion
brain development
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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