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Invitrogen
AMOTL2 Polyclonal Antibody
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FIGURE: 1 / 3
AMOTL2 Antibody (PA5-120481) in IHC (P)
Immunohistochemistry analysis of AMOTL2 in paraffin-embedded human liver cancer. Samples were incubated with AMOTL2 Polyclonal antibody (Product # PA5-120481) using a dilution of 1:200 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-120481
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 638-837 of human AMOTL2 (NP_001265612.1).
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914053
Product Specific Information
Positive test controls include: 293T, U-251MG, HepG2, Mouse liver, Mouse brain.
Immunogen sequence: RQFAMDAAAT AAAQRDTTLI RHSPQPSPSS SFNEGLLTGG HRHQEMESRL KVLHAQILEK DAVIKVLQQR SRRDPGKAIQ GSLRPAKSVP SVFAAAAAGT QGWQGLSSSE RQTADAPARL TTDRAPTEEP VVTAPPAAHA KHGSRDGSTQ TEGPPDSTST CLPPEPDSLL GCSSSQRAAS LDSVATSRVQ DLSDMVEILI
Target Information
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: angiomotin like 2; Angiomotin-like protein 2; LCCP; Leman coiled-coil protein
Gene Aliases: AMOTL2; AW549739; C79691; KIAA0989; LCCP; MASCOT; mKIAA0989
UniProt ID: (Human) Q9Y2J4, (Mouse) Q8K371
Entrez Gene ID: (Human) 51421, (Mouse) 56332
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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