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Invitrogen
AMPK beta-1 Recombinant Rabbit Monoclonal Antibody (SD082-06)
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FIGURE: 1 / 4
AMPK beta-1 Antibody (MA5-41187) in ICC/IF
Immunocytochemistry analysis of AMPK beta-1 with C2C12 cells. Cells were fixed in 4% paraformaldehyde (20 min, room temp), permeabilized with 0.1% Triton X-100 in PBS (5 min, room temp), then blocked with 1% BSA in 10% negative goat serum (1 hr, room temp), incubated with recombinant monoclonal AMPK beta-1 (Product # MA5-41187) at a dilution of 1:100 (in 1% BSA in PBST overnight at 4°C), followed by Goat An... View More
Product Details
MA5-41187
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SD082-06
Immunogen
Synthetic peptide within human AMPK beta 1 aa 90-130
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898941
Target Information
AMPK beta 1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-AMP-activated protein kinase 40 kDa subunit; 5'-AMP-activated protein kinase beta-1 subunit; 5'-AMP-activated protein kinase subunit beta-1; 5'-AMP-activated protein kinase, beta subunit; 5-AMP-activated protein kinase beta subunit; AAKB1; AMP-activated protein kinase beta subunit; AMPK beta -1 chain; AMPK beta 1; AMPK beta-1 chain; AMPK subunit beta-1; AMPK-beta1; AMPKb; kinase AMPK-beta1; kinase pAMPK; pAMPK; protein kinase, AMP-activated, beta 1 non-catalytic subunit; protein kinase, AMP-activated, noncatalytic, beta-1
Gene Aliases: 1300015D22Rik; AMPK; AU021155; E430008F22; HAMPKb; PRKAB1
UniProt ID: (Human) Q9Y478, (Mouse) Q9R078, (Rat) P80386
Entrez Gene ID: (Human) 5564, (Mouse) 19079, (Rat) 83803
protein phosphorylation
fatty acid biosynthetic process
cell cycle arrest
signal transduction
positive regulation of gene expression
macroautophagy
regulation of protein kinase activity
protein heterooligomerization
regulation of signal transduction by p53 class mediator
lipid metabolic process
fatty acid metabolic process
regulation of catalytic activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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