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Product Details
BS-9446R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PRKAG2/AMPK_2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The 5-AMP activated protein kinase (AMPK), a member of the SNF1 (sucrose non fermentor) kinase family, is a heterotrimeric protein comprise of alpha (63 kDa), beta (30 kDa) and gamma (38 kDa) subunits. The alpha subunit is the catalytic subunit, while beta and gamma are non catalytic subunits (although they have been found to interact with the active subunit in liver). AMPK regulates fatty acid and sterol synthesis by phosphorylation of acetyl-CoA as well as cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase. AMPK is activated by AMP and can be also regulated by treatment with purified protein phosphatase in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-AMP-activated protein kinase subunit gamma-1; 5'-AMP-activated protein kinase subunit gamma-2; 5'-AMP-activated protein kinase subunit gamma-3; 5'-AMP-activated protein kinase, gamma-1 subunit; 5'-AMP-activated protein kinase, gamma-3 subunit; 5-AMP-activated protein kinase, gamma-2 subunit; adenosine monophosphate-activated protein kinase gamma 2-subunit; AMP-activated protein kinase gamma 3 subunit; AMP-activated protein kinase gamma subunit; AMP-activated protein kinase gamma2 subunit; AMP-activated protein kinase, noncatalytic gamma-1 subunit; ampk gamma; AMPK gamma 2; AMPK gamma-1 chain; AMPK gamma-2 chain; AMPK gamma-3 chain; AMPK gamma1; AMPK gamma2; AMPK gamma3; AMPK subunit gamma-1; AMPK subunit gamma-2; AMPK subunit gamma-3; AMPK- gamma1; AMPK- gamma2; AMPK- gamma3; AMPKg; H91620p; Protein kinase AMP-activated gamma; protein kinase, AMP-activated, gamma 1 non-catalytic subunit; protein kinase, AMP-activated, gamma 2 non-catalytic subunit; protein kinase, AMP-activated, gamma 3 non-catalytic subunit; protein kinase, AMP-activated, gamma 3 non-catatlytic subunit
Gene Aliases: 2410051C13Rik; AA571379; AAKG; AAKG2; AI854673; Amkg3; AMPKG; AMPKG3; AMPKg3L; AMPKg3S; BB036179; CMH6; H91620p; Prkaac; PRKAG1; PRKAG2; PRKAG3; Prkga1; WPWS
UniProt ID: (Human) P54619, (Human) Q9UGJ0, (Human) Q9UGI9, (Mouse) O54950, (Rat) P80385, (Mouse) Q91WG5, (Mouse) Q8BGM7
Entrez Gene ID: (Human) 5571, (Human) 51422, (Human) 53632, (Mouse) 19082, (Rat) 25520, (Rat) 373545, (Mouse) 108099, (Rat) 301518, (Mouse) 241113
protein kinase activity
AMP-activated protein kinase activity
cAMP-dependent protein kinase activity
protein binding
ATP binding
cAMP-dependent protein kinase regulator activity
AMP binding
protein kinase binding
ADP binding
cAMP-dependent protein kinase inhibitor activity
phosphorylase kinase regulator activity
protein kinase activator activity
nucleotide binding
glycogen biosynthetic process
protein phosphorylation
glucose transport
glycogen metabolic process
regulation of glycolytic process
negative regulation of protein kinase activity
fatty acid biosynthetic process
ATP biosynthetic process
carnitine shuttle
cell cycle arrest
positive regulation of peptidyl-threonine phosphorylation
sterol biosynthetic process
macroautophagy
regulation of fatty acid metabolic process
activation of protein kinase activity
intracellular signal transduction
regulation of fatty acid biosynthetic process
positive regulation of protein kinase activity
regulation of fatty acid oxidation
regulation of glucose import
negative regulation of protein serine/threonine kinase activity
regulation of signal transduction by p53 class mediator
lipid metabolic process
fatty acid metabolic process
signal transduction
spermatogenesis
positive regulation of gene expression
regulation of catalytic activity
protein heterooligomerization
Performance Guarantee
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