Proteintech

AMPK gamma2 Polyclonal Antibody

AMPK gamma2 Antibody in Immunocytochemistry (ICC/IF)

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AMPK gamma2 Antibody (12568-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 12568-1-AP (AMPK gamma2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

AMPK gamma2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

AMPK gamma2 Antibody in Western Blot (WB)

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Product Details

12568-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

AMPK gamma2 Fusion Protein Ag3214 (11-341 aa encoded by BC020540)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: EAGMLEKLE FEDEAVEDSE SGVYMRFMRS HKCYDIVPTS SKLVVFDTTL QVKKAFFALV ANGVRAAPLW ESKKQSFVGM LTITDFINIL HRYYKSPMVQ IYELEEHKIE TWRELYLQET FKPLVNISPD ASLFDAVYSL IKNKIHRLPV IDPISGNALY ILTHKRILKF LQLFMSDMPK PAFMKQNLDE LGIGTYHNIA FIHPDTPIIK ALNIFVERRI SALPVVDESG KVVDIYSKFD VINLAAEKTY NNLDITVTQA LQHRSQYFEG VVKCNKLEIL ETIVDRIVRA EVHRLVVVNE ADSIVGIISL SDILQALILT PAGAKQKETE TE (11-341 aa encoded by BC020540)

Target Information

AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.

Journal of medicinal chemistry

Sheng Y,Chen Y,Zeng Z,Wu W,Wang J,Ma Y,Lin Y,Zhang J,Huang Y,Li W,Zhu Q,Wei X,Li S,Wisanwattana W,Li F,Liu W,Suksamrarn A,Zhang G,Jiao W,Wang F

Thu Jan 13 00:00:00 UTC 2022

Identification and functional analysis of a novel PRKAG2 mutation responsible for Chinese PRKAG2 cardiac syndrome reveal an important role of non-CBS domains in regulating the AMPK pathway.

Journal of cardiology

Zhang BL,Xu RL,Zhang J,Zhao XX,Wu H,Ma LP,Hu JQ,Zhang JL,Ye Z,Zheng X,Qin YW

Tue Oct 01 00:00:00 UTC 2013

Identification and functional analysis of a novel PRKAG2 mutation responsible for Chinese PRKAG2 cardiac syndrome reveal an important role of non-CBS domains in regulating the AMPK pathway.

Journal of cardiology

Zhang BL,Xu RL,Zhang J,Zhao XX,Wu H,Ma LP,Hu JQ,Zhang JL,Ye Z,Zheng X,Qin YW

Tue Oct 01 00:00:00 UTC 2013

Identification and functional analysis of a novel PRKAG2 mutation responsible for Chinese PRKAG2 cardiac syndrome reveal an important role of non-CBS domains in regulating the AMPK pathway.

Journal of cardiology

Zhang BL,Xu RL,Zhang J,Zhao XX,Wu H,Ma LP,Hu JQ,Zhang JL,Ye Z,Zheng X,Qin YW

Tue Oct 01 00:00:00 UTC 2013

Identification and functional analysis of a novel PRKAG2 mutation responsible for Chinese PRKAG2 cardiac syndrome reveal an important role of non-CBS domains in regulating the AMPK pathway.

Journal of cardiology

Zhang BL,Xu RL,Zhang J,Zhao XX,Wu H,Ma LP,Hu JQ,Zhang JL,Ye Z,Zheng X,Qin YW

Tue Oct 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: 5'-AMP-activated protein kinase subunit gamma-2; 5-AMP-activated protein kinase, gamma-2 subunit; ampk gamma; AMPK gamma-2 chain; AMPK gamma2; AMPK subunit gamma-2; H91620p; OTTHUMP00000211956; protein kinase, AMP-activated, gamma 2 non-catalytic subunit

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Gene Aliases: 2410051C13Rik; AAKG; AAKG2; AI854673; CMH6; H91620p; PRKAG2; WPWS

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UniProt ID: (Human) Q9UGJ0, (Mouse) Q91WG5

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Entrez Gene ID: (Human) 51422, (Mouse) 108099

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Function(s)

AMP-activated protein kinase activity cAMP-dependent protein kinase inhibitor activity ATP binding cAMP-dependent protein kinase regulator activity phosphorylase kinase regulator activity AMP binding protein kinase binding protein kinase activator activity ADP binding nucleotide binding

Process(es)

glycogen metabolic process regulation of glycolytic process protein phosphorylation negative regulation of protein kinase activity fatty acid biosynthetic process ATP biosynthetic process carnitine shuttle cell cycle arrest positive regulation of peptidyl-threonine phosphorylation sterol biosynthetic process macroautophagy regulation of fatty acid metabolic process activation of protein kinase activity intracellular signal transduction regulation of fatty acid biosynthetic process positive regulation of protein kinase activity regulation of fatty acid oxidation regulation of glucose import negative regulation of protein serine/threonine kinase activity regulation of signal transduction by p53 class mediator lipid metabolic process fatty acid metabolic process regulation of catalytic activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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AMPK gamma2 Polyclonal Antibody

AMPK gamma2 Antibody (12568-1-AP) in ICC/IF

Product Details

12568-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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