Proteintech

ANKRD1 Polyclonal Antibody

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ANKRD1 Antibody (11427-1-AP) in WB

Mouse skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 11427-1-AP (ANKRD1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Product Details

11427-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 10 publications 10 publications

Immunocytochemistry (ICC/IF)

Assay-dependent

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ANKRD1 Fusion Protein Ag1970 (1-319 aa encoded by BC018667)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This is a rabbit polyclonal antibody produced by the full-length ANKRD1 of human origin.

Immunogen sequence: MMVLKVEEL VTGKKNGNGE AGEFLPEDFR DGEYEAAVTL EKQEDLKTLL AHPVTLGEQQ WKSEKQREAE LKKKKLEQRS KLENLEDLEI IIQLKKRKKY RKTKVPVVKE PEPEIITEPV DVPTFLKAAL ENKLPVVEKF LSDKNNPDVC DEYKRTALHR ACLEGHLAIV EKLMEAGAQI EFRDMLESTA IHWASRGGNL DVLKLLLNKG AKISARDKLL STALHVAVRT GHYECAEHLI ACEADLNAKD REGDTPLHDA VRLNRYKMIR LLIMYGADLN IKNCAGKTPM DLVLHWQNGT KAIFDSLREN SYKTSRIATF (1-319 aa encoded by BC018667)

Target Information

The protein encoded by this gene is localized to the nucleus of endothelial cells and is induced by IL-1 and TNF-alpha stimulation. Studies in rat cardiomyocytes suggest that this gene functions as a transcription factor. Interactions between this protein and the sarcomeric proteins myopalladin and titin suggest that it may also be involved in the myofibrillar stretch-sensor system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Integrated transcriptomic and proteomic analysis reveals potential targets for heart regeneration.

Biomolecules & biomedicine

Liu L,Yang T,Jiang Q,Sun J,Gu L,Wang S,Li Y,Chen B,Zhao D,Sun R,Wang Q,Wang H,Wang L

Wed Feb 01 00:00:00 UTC 2023

α-Arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis.

Journal of cell science

Arakaki AKS,Pan WA,Wedegaertner H,Roca-Mercado I,Chinn L,Gujral TS,Trejo J

Thu Apr 15 00:00:00 UTC 2021

ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.

Nature communications

Taftaf R,Liu X,Singh S,Jia Y,Dashzeveg NK,Hoffmann AD,El-Shennawy L,Ramos EK,Adorno-Cruz V,Schuster EJ,Scholten D,Patel D,Zhang Y,Davis AA,Reduzzi C,Cao Y,D'Amico P,Shen Y,Cristofanilli M,Muller WA,Varadan V,Liu H

Wed Aug 11 00:00:00 UTC 2021

Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wei L,Cao P,Xu C,Zhong H,Wang X,Bai M,Hu B,Wang R,Liu N,Tian Y,Chen H,Li J,Yuan W

Tue Dec 01 00:00:00 UTC 2020

YAP1/TAZ drives ependymoma-like tumour formation in mice.

Nature communications

Eder N,Roncaroli F,Domart MC,Horswell S,Andreiuolo F,Flynn HR,Lopes AT,Claxton S,Kilday JP,Collinson L,Mao JH,Pietsch T,Thompson B,Snijders AP,Ultanir SK

Wed May 13 00:00:00 UTC 2020

Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.

American journal of physiology. Lung cellular and molecular physiology

Dieffenbach PB,Haeger CM,Coronata AMF,Choi KM,Varelas X,Tschumperlin DJ,Fredenburgh LE

Fri Sep 01 00:00:00 UTC 2017

Arterial stiffness induces remodeling phenotypes in pulmonary artery smooth muscle cells via YAP/TAZ-mediated repression of cyclooxygenase-2.

American journal of physiology. Lung cellular and molecular physiology

Dieffenbach PB,Haeger CM,Coronata AMF,Choi KM,Varelas X,Tschumperlin DJ,Fredenburgh LE

Fri Sep 01 00:00:00 UTC 2017

The histone code reader Spin1 controls skeletal muscle development.

Cell death & disease

Greschik H,Duteil D,Messaddeq N,Willmann D,Arrigoni L,Sum M,Jung M,Metzger D,Manke T,Günther T,Schüle R

Thu Nov 23 00:00:00 UTC 2017

The histone code reader Spin1 controls skeletal muscle development.

Cell death & disease

Greschik H,Duteil D,Messaddeq N,Willmann D,Arrigoni L,Sum M,Jung M,Metzger D,Manke T,Günther T,Schüle R

Thu Nov 23 00:00:00 UTC 2017

Glucocorticoid receptor signalling activates YAP in breast cancer.

Nature communications

Sorrentino G,Ruggeri N,Zannini A,Ingallina E,Bertolio R,Marotta C,Neri C,Cappuzzello E,Forcato M,Rosato A,Mano M,Bicciato S,Del Sal G

Thu Jan 19 00:00:00 UTC 2017

Glucocorticoid receptor signalling activates YAP in breast cancer.

Nature communications

Sorrentino G,Ruggeri N,Zannini A,Ingallina E,Bertolio R,Marotta C,Neri C,Cappuzzello E,Forcato M,Rosato A,Mano M,Bicciato S,Del Sal G

Thu Jan 19 00:00:00 UTC 2017

Characterization of muscle ankyrin repeat proteins in human skeletal muscle.

American journal of physiology. Cell physiology

Wette SG,Smith HK,Lamb GD,Murphy RM

Fri Sep 01 00:00:00 UTC 2017

Exploiting the CRISPR/Cas9 system to study alternative splicing in vivo: application to titin.

Human molecular genetics

Charton K,Suel L,Henriques SF,Moussu JP,Bovolenta M,Taillepierre M,Becker C,Lipson K,Richard I

Sat Oct 15 00:00:00 UTC 2016

Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chadwick JA,Hauck JS,Lowe J,Shaw JJ,Guttridge DC,Gomez-Sanchez CE,Gomez-Sanchez EP,Rafael-Fortney JA

Sun Nov 01 00:00:00 UTC 2015

Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chadwick JA,Hauck JS,Lowe J,Shaw JJ,Guttridge DC,Gomez-Sanchez CE,Gomez-Sanchez EP,Rafael-Fortney JA

Sun Nov 01 00:00:00 UTC 2015

Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chadwick JA,Hauck JS,Lowe J,Shaw JJ,Guttridge DC,Gomez-Sanchez CE,Gomez-Sanchez EP,Rafael-Fortney JA

Sun Nov 01 00:00:00 UTC 2015

Mineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chadwick JA,Hauck JS,Lowe J,Shaw JJ,Guttridge DC,Gomez-Sanchez CE,Gomez-Sanchez EP,Rafael-Fortney JA

Sun Nov 01 00:00:00 UTC 2015

Metabolic control of YAP and TAZ by the mevalonate pathway.

Nature cell biology

Sorrentino G,Ruggeri N,Specchia V,Cordenonsi M,Mano M,Dupont S,Manfrin A,Ingallina E,Sommaggio R,Piazza S,Rosato A,Piccolo S,Del Sal G

Tue Apr 01 00:00:00 UTC 2014

Metabolic control of YAP and TAZ by the mevalonate pathway.

Nature cell biology

Sorrentino G,Ruggeri N,Specchia V,Cordenonsi M,Mano M,Dupont S,Manfrin A,Ingallina E,Sommaggio R,Piazza S,Rosato A,Piccolo S,Del Sal G

Tue Apr 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: ankyrin repeat domain 1 (cardiac muscle); Ankyrin repeat domain-containing protein 1; ankyrin-like repeat protein; Cardiac adriamycin-responsive protein; Cardiac ankyrin repeat protein; cardiac responsive adriamycin protein; Cytokine-inducible gene C-193 protein; Cytokine-inducible nuclear protein; liver ankyrin repeat domain 1; muscle ankyrin repeat protein

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Gene Aliases: ALRP; ANKRD1; bA320F15.2; C-193; C193; CARP; Crap; CVARP; HA1A2; MARP; MARP1; MCARP

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UniProt ID: (Human) Q15327, (Mouse) Q9CR42, (Rat) Q8R560

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Entrez Gene ID: (Human) 27063, (Mouse) 107765, (Rat) 27064

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Function(s)

RNA polymerase II transcription factor binding RNA polymerase II transcription coactivator activity p53 binding DNA binding transcription corepressor activity protein binding titin binding histone deacetylase binding R-SMAD binding transcription factor binding transcription cofactor activity

Process(es)

negative regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter positive regulation of neuron projection development cellular response to drug skeletal muscle cell differentiation response to muscle stretch positive regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of transcription from RNA polymerase II promoter positive regulation of protein secretion cardiac muscle tissue morphogenesis cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to transforming growth factor beta stimulus negative regulation of nucleic acid-templated transcription negative regulation of DNA biosynthetic process muscle cell differentiation negative regulation of transcription, DNA-templated cellular response to organic cyclic compound cellular response to hypoxia sarcomere organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ANKRD1 Polyclonal Antibody

ANKRD1 Antibody (11427-1-AP) in WB

Product Details

11427-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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