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ANT1/2 Polyclonal Antibody

ANT1/2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ANT1/2 Antibody (17796-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney using 17796-1-AP (ANT1/2 antibody) at dilution of 1:100 (under 40x lens).

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Product Details

17796-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ANT1/2 Fusion Protein Ag11956 (1-298 aa encoded by BC056160)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody recognizes both of ANT1 and ANT2. The predicted molecular weight of ANT1/2 protein is around 32 kDa. While 60 kDa protein can also be observed, which has been proposed as the dimmer of ANT1/2.

Immunogen sequence: MTDAAVSFA KDFLAGGVAA AISKTAVAPI ERVKLLLQVQ HASKQITADK QYKGIIDCVV RIPKEQGVLS FWRGNLANVI RYFPTQALNF AFKDKYKQIF LGGVDKRTQF WRYFAGNLAS GGAAGATSLC FVYPLDFART RLAADVGKAG AEREFRGLGD CLVKIYKSDG IKGLYQGFNV SVQGIIIYRA AYFGIYDTAK GMLPDPKNTH IVISWMIAQT VTAVAGLTSY PFDTVRRRMM MQSGRKGTDI MYTGTLDCWR KIARDEGGKA FFKGAWSNVL RGMGGAFVLV LYDEIKKYT (1-298 aa encoded by BC056160 )

Target Information

Adenine nucleotide translocator (ANT) and the voltage-dependent anion-selective channel proteins 1 and 2 (VDAC1 and VDAC2) are components of the permeability transition pore complex (PTPC) of the mitochondrial inner and outer membranes, respectively. Formation of PTPCs, the subsequent dissipation of mitochondrial inner membrane potential and release of cytochrome c through the outer mitochondrial membrane are critical events in the early stages of apoptosis. Bax, a proapoptotic protein, has been shown to act upon ANT to induce the dissipation of mitochondrial inner membrane potential. ANT1 has a role in the maintenance of mitochondrial DNA by catalyzing the exchange of ADP and ATP across the mitochondrial inner membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases.

eLife

Fu J,Zhou M,Gritsenko MA,Nakayasu ES,Song L,Luo ZQ

Thu Jan 27 00:00:00 UTC 2022

Combined effects of aerobic exercise and 40-Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3×Tg mice.

Journal of applied physiology (Bethesda, Md. : 1985)

Park SS,Park HS,Kim CJ,Baek SS,Park SY,Anderson C,Kim MK,Park IR,Kim TW

Fri Apr 01 00:00:00 UTC 2022

Biomarker Expression Profiling in Cervix Carcinoma Biopsies Unravels WT1 as a Target of Artesunate.

Cancer genomics & proteomics

Saeed MEM,Cives-Losada C,Efferth T

Wed Nov 02 00:00:00 UTC 2022

Identification and validation of necroptosis-related prognostic gene signature and tumor immune microenvironment infiltration characterization in esophageal carcinoma.

BMC gastroenterology

Sun K,Hong JJ,Chen DM,Luo ZX,Li JZ

Fri Jul 15 00:00:00 UTC 2022

TERT Promoter Revertant Mutation Inhibits Melanoma Growth through Intrinsic Apoptosis.

Biology

Wang Y,Chen Y,Li C,Xiao Z,Yuan H,Zhang Y,Pang D,Tang X,Li M,Ouyang H

Fri Jan 14 00:00:00 UTC 2022

Identification of a necroptosis-related prognostic gene signature associated with tumor immune microenvironment in cervical carcinoma and experimental verification.

World journal of surgical oncology

Sun K,Huang C,Li JZ,Luo ZX

Mon Oct 17 00:00:00 UTC 2022

Proteomic Identification of the SLC25A46 Interactome in Transgenic Mice Expressing SLC25A46-FLAG.

Journal of proteome research

Perivolidi VI,Violitzi F,Ioannidou E,Rinotas V,Stamatakis G,Samiotaki M,Panayotou G,Douni E

Fri Feb 04 00:00:00 UTC 2022

Adenine Nucleotide Translocase 2 as an Enzyme Related to [¹⁸F] FDG Accumulation in Various Cancers.

Molecular imaging and biology

Lee CH,Kim MJ,Lee HH,Paeng JC,Park YJ,Oh SW,Chai YJ,Kim YA,Cheon GJ,Kang KW,Youn H,Chung JK

Thu Aug 01 00:00:00 UTC 2019

Adenine Nucleotide Translocase 2 as an Enzyme Related to [¹⁸F] FDG Accumulation in Various Cancers.

Molecular imaging and biology

Lee CH,Kim MJ,Lee HH,Paeng JC,Park YJ,Oh SW,Chai YJ,Kim YA,Cheon GJ,Kang KW,Youn H,Chung JK

Thu Aug 01 00:00:00 UTC 2019

Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder.

Experimental neurology

Seo JH,Park HS,Park SS,Kim CJ,Kim DH,Kim TW

Sun Dec 01 00:00:00 UTC 2019

Downregulation of microRNA‑199a‑5p attenuates hypoxia/reoxygenation‑induced cytotoxicity in cardiomyocytes by targeting the HIF‑1α‑GSK3β‑mPTP axis.

Molecular medicine reports

Liu DW,Zhang YN,Hu HJ,Zhang PQ,Cui W

Sat Jun 01 00:00:00 UTC 2019

Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.

Journal of proteome research

Violitzi F,Perivolidi VI,Thireou T,Grivas I,Haralambous S,Samiotaki M,Panayotou G,Douni E

Fri Nov 01 00:00:00 UTC 2019

Novel insights into SLC25A46-related pathologies in a genetic mouse model.

PLoS genetics

Terzenidou ME,Segklia A,Kano T,Papastefanaki F,Karakostas A,Charalambous M,Ioakeimidis F,Papadaki M,Kloukina I,Chrysanthou-Piterou M,Samiotaki M,Panayotou G,Matsas R,Douni E

Sat Apr 01 00:00:00 UTC 2017

Novel insights into SLC25A46-related pathologies in a genetic mouse model.

PLoS genetics

Terzenidou ME,Segklia A,Kano T,Papastefanaki F,Karakostas A,Charalambous M,Ioakeimidis F,Papadaki M,Kloukina I,Chrysanthou-Piterou M,Samiotaki M,Panayotou G,Matsas R,Douni E

Sat Apr 01 00:00:00 UTC 2017

Proteomics of skin proteins in psoriasis: from discovery and verification in a mouse model to confirmation in humans.

Molecular & cellular proteomics : MCP

Lundberg KC,Fritz Y,Johnston A,Foster AM,Baliwag J,Gudjonsson JE,Schlatzer D,Gokulrangan G,McCormick TS,Chance MR,Ward NL

Thu Jan 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Adenine nucleotid translocator 2 fibroblast isoform (ATP-ADP carrier protein); Adenine nucleotid translocator 2, fibroblast isoform (ATP-ADP carrier protein); adenine nucleotide translocase-1; Adenine nucleotide translocator 1; adenine nucleotide translocator 1 (skeletal muscle); adenine nucleotide translocator 1, skeletal muscle; Adenine nucleotide translocator 2; adenine nucleotide translocator 2 (fibroblast); adenine nucleotide translocator 2 fibroblast isoform (ATP-ADP carrier protein); adenine nucleotide translocator 2, fibroblast isoform (ATP-ADP carrier protein); ADP,ATP carrier protein 1; ADP,ATP carrier protein 2; ADP,ATP carrier protein, fibroblast isoform; ADP,ATP carrier protein, heart/skeletal muscle; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; ADP/ATP translocase 1; ADP/ATP translocase 2; ANT 1; ANT 2; heart/skeletal muscle ATP/ADP translocator; mANC1; mitochondrial adenine nucleotide translocator; solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Solute carrier family 25 member 4; Solute carrier family 25 member 5

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Gene Aliases: 2F1; AAC1; AAC2; Anc1; ANT; ANT 1; ANT1; ANT2; AU019225; MTDPS12; PEO2; PEO3; PEOA2; SLC25A4; SLC25A5; T1; T2; T3

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UniProt ID: (Human) P12235, (Human) P05141, (Rat) Q05962, (Mouse) P48962, (Rat) Q09073, (Mouse) P51881

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Entrez Gene ID: (Human) 291, (Human) 292, (Rat) 85333, (Mouse) 11739, (Rat) 25176, (Mouse) 11740

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Function(s)

structural constituent of ribosome protein binding adenine transmembrane transporter activity ubiquitin protein ligase binding poly(A) RNA binding transporter activity enzyme binding

Process(es)

liver development heart development aging apoptotic mitochondrial changes negative regulation of cardiac muscle cell apoptotic process transmembrane transport negative regulation of necroptotic process positive regulation of cell growth involved in cardiac muscle cell development response to interleukin-1 negative regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of oxidative phosphorylation uncoupler activity chromosome segregation positive regulation of cell proliferation negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway mitochondrial genome maintenance generation of precursor metabolites and energy translation transport adenine transport viral process regulation of insulin secretion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ANT1/2 Polyclonal Antibody

ANT1/2 Antibody (17796-1-AP) in IHC (P)

Product Details

17796-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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