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Product Details
15091-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ANTXR1 Fusion Protein Ag4626 (1-318 aa encoded by BC012074)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MATAERRAL GIGFQWLSLA TLVLICAGQG GRREDGGPAC YGGFDLYFIL DKSGSVLHHW NEIYYFVEQL AHKFISPQLR MSFIVFSTRG TTLMKLTEDR EQIRQGLEEL QKVLPGGDTY MHEGFERASE QIYYENRQGY RTASVIIALT DGELHEDLFF YSEREANRSR DLGAIVYCVG VKDFNETQLA RIADSKDHVF PVNDGFQALQ GIIHSILKKS CIEILAAEPS TICAGESFQV VVRGNGFRHA RNVDRVLCSF KINDSVTLNE KPFSVEDTYL LCPAPILKEV GMKAALQVSM NDGLSFISSS VIITTTHCS (1-318 aa encoded by BC012074 )
Target Information
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2310008J16Rik; 2810405N18Rik; anthrax toxin receptor; Anthrax toxin receptor 1; FLJ10601; FLJ11298; FLJ21776; Tem-8; Tumor endothelial marker 8
Gene Aliases: 2310008J16Rik; 2810405N18Rik; Antrx1; ANTXR1; ATR; GAPO; TEM8
UniProt ID: (Human) Q9H6X2, (Rat) Q0PMD2, (Mouse) Q9CZ52
Entrez Gene ID: (Human) 84168, (Rat) 362393, (Mouse) 69538
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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