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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • AP2 alpha Antibodies

          Invitrogen

          AP2 alpha Monoclonal Antibody (R.387.0)

          1 Published Figure
          3 References
          View all (18) AP2 alpha antibodies

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          Datasheet
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          Datasheet
          Protocols
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          Cite AP2 alpha Monoclonal Antibody (R.387.0)

          • Antibody Testing Data (2)
          • Published Figures (1)
          AP2 alpha Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          AP2 alpha Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 3

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          AP2 alpha Antibody (MA5-14856) in ICC/IF

          Immunofluorescent analysis of AP-2-alpha in HeLa cells using an AP-2-alpha monoclonal antibody (Product # MA5-14856) (green). Actin filaments are labeled with a fluorescent red phalloidin. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          AP2 alpha Antibody in Immunocytochemistry (ICC/IF)
          AP2 alpha Antibody in Western Blot (WB)
          AP2 alpha Antibody in Immunocytochemistry (ICC/IF)

          Product Details

          MA5-14856

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000
          View 1 publication 1 publication

          Immunocytochemistry (ICC/IF)

          1:100
          View 2 publications 2 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Non-human primate, Rat

          Published species

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Monoclonal

          Type

          Antibody

          Clone

          R.387.0

          Immunogen

          Synthetic peptide corresponding to human AP-2a

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          94.8 µg/mL

          Purification

          Affinity chromatography

          Storage buffer

          0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

          Contains

          <0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_10982796

          Product Specific Information

          It is not recommended to aliquot this antibody.

          Target Information

          TFAP2A is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2A is the only AP-2 protein required for early morphogenesis of the lens vesicle.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: activating enhancer-binding protein 2 alpha; Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2; AP-2 transcription factor; AP2-alpha; ERF-1; FLJ51761; OTTHUMP00000214240; OTTHUMP00000214243; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Transcription factor AP-2-alpha

          View more View less

          Gene Aliases: AP-2; Ap-2 (a); AP-2alpha; Ap2; AP2alpha; AP2TF; BOFS; Tcfap2a; TFAP2; TFAP2A

          View more View less

          UniProt ID: (Human) P05549, (Mouse) P34056

          View more View less

          Entrez Gene ID: (Human) 7020, (Mouse) 21418, (Rat) 306862

          View more View less

          Function(s)
          transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription coactivator activity protein binding transcription factor binding protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding protein dimerization activity RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription coactivator activity RNA polymerase II transcription corepressor activity transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter kidney development neural tube closure lens morphogenesis in camera-type eye outflow tract morphogenesis keratinocyte development optic vesicle morphogenesis optic cup structural organization transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter sensory perception of sound negative regulation of cell proliferation embryonic pattern specification embryonic body morphogenesis positive regulation of gene expression negative regulation of transcription by competitive promoter binding neural crest cell development anterior neuropore closure trigeminal nerve development oculomotor nerve formation forebrain neuron development positive regulation of cell migration positive regulation of bone mineralization response to lipopolysaccharide embryonic forelimb morphogenesis forelimb morphogenesis negative regulation of epidermal growth factor receptor signaling pathway inner ear morphogenesis negative regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of neuron apoptotic process skin development regulation of cell differentiation regulation of neuron differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter sympathetic nervous system development embryonic camera-type eye morphogenesis embryonic cranial skeleton morphogenesis skeletal system morphogenesis epidermis morphogenesis palate development lens induction in camera-type eye face morphogenesis bone morphogenesis eyelid development in camera-type eye cornea development in camera-type eye positive regulation of tooth mineralization cellular response to iron ion basement membrane organization negative regulation of reactive oxygen species metabolic process response to water deprivation response to organic substance retina layer formation Schwann cell development regulation of cell proliferation metanephric nephron development
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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