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AP2 gamma Antibody (PA5-121134) in WB
Western blot analysis of AP2 gamma in extracts of various cell lines. Samples were incubated with AP2 gamma Polyclonal antibody (Product # PA5-121134) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-121134
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human TFAP2C (NP_003213.1).
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914706
Product Specific Information
Positive test controls include: HeLa, Mouse lung, Rat lung. The target is usually found in the following locations: Nucleus.
Immunogen sequence: NMLLAAQQLC KEFTELLSQD RTPHGTSRLA PVLETNIQNC LSHFSLITHG FGSQAICAAV SALQNYIKEA LIVIDKSYMN PGDQSPADSN KTLEKMEKHR K
Target Information
The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activating enhancer binding protein 2 gamma; Activating enhancer-binding protein 2 gamma; activator protein 2 gamma; AP-2.2; AP2-gamma; estrogen receptor factor 1; stimulated by retinoic acid gene 2; Transcription factor AP-2 gamma; transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma); transcription factor AP-2 gamma (activating enhancer-binding protein 2 gamma); Transcription factor ERF-1
Gene Aliases: AA409384; Ap-2.2; AP2-GAMMA; AP2gamma; ERF1; hAP-2g; Stra2; Tcfap2c; TFAP2C; TFAP2G
UniProt ID: (Human) Q92754, (Mouse) Q61312
Entrez Gene ID: (Human) 7022, (Rat) 362280, (Mouse) 21420
RNA polymerase II regulatory region sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein dimerization activity
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
molecular_function
negative regulation of transcription from RNA polymerase II promoter
trophectodermal cell differentiation
hair follicle development
keratinocyte development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
biological_process
male gonad development
stem cell population maintenance
forebrain neuron fate commitment
cerebral cortex development
cell differentiation
germ-line stem cell population maintenance
somatic stem cell population maintenance
regulation of gene expression, epigenetic
regulation of cell proliferation
skin development
regulation of epidermis development
positive regulation of transcription from RNA polymerase II promoter
sebaceous gland development
anatomical structure development
dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
epithelial cell proliferation involved in mammary gland duct elongation
cell-cell signaling
transcription, DNA-templated
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